Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

• Published in: Nature medicine Vol. 24; no. 4; pp. 417 - 426
• Main Authors: Baral, Pankaj, Umans, Benjamin D, Li, Lu, Wallrapp, Antonia, Bist, Meghna, Kirschbaum, Talia, Wei, Yibing, Zhou, Yan, Kuchroo, Vijay K, Burkett, Patrick R, Yipp, Bryan G, Liberles, Stephen D, Chiu, Isaac M
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.05.2018; Nature Publishing Group
• Subjects: 13/21; 13/51; 14/63; 14/69; 631/250/255; 631/250/371; 631/326/41; 631/378/371; 64/60; 96/106; 96/31; Ablation; Biomedicine; Body temperature; Bronchoconstriction; Bronchopulmonary infection; Calcitonin; Calcitonin gene-related peptide; Cancer Research; Capsaicin receptors; Cell survival; Critical care; Defense; Drug dosages; Ganglia; Heat; Hospitals; Immunity (Disease); Immunosuppression; Infectious Diseases; Innate immunity; Leukocytes (neutrophilic); Lungs; Lymphocytes; Lymphocytes T; Medicine; Metabolic Diseases; Molecular Medicine; Neurons; Neurosciences; Neutrophils; Nociceptors; Nosocomial infections; Pain perception; Pathogens; Pneumonia; Sensory neurons; Staphylococcus infections; Streptococcus infections; Toxins; Vagus nerve

Nociceptor sensory neurons suppress innate immunity during bacterial lung infection. Lung-innervating nociceptor sensory neurons detect noxious or harmful stimuli and consequently protect organisms by mediating coughing, pain, and bronchoconstriction. However, the role of sensory neurons in pulmonar...