Fabrication of Ibrutinib Nanosuspension by Quality by Design Approach: Intended for Enhanced Oral Bioavailability and Diminished Fast Fed Variability - Rangaraj, Nagarjun; Pailla, Sravanthi Reddy; Chowta, Paramesh; Sampathi, Sunitha (AAPS PharmSciTech, 2019)
Keywords: Administration, Oral; Animals; Biochemistry; Biological Availability; Biomedical and Life Sciences; Biomedicine; Biotechnology; Calorimetry, Differential Scanning; Drug Design; Male; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Nanoparticles - metabolism; Particle Size; Pharmacology/Toxicology; Pharmacy; Poloxamer - chemistry; Pyrazoles - administration & dosage; Pyrazoles - chemical synthesis; Pyrazoles - metabolism; Pyrimidines - administration & dosage; Pyrimidines - chemical synthesis; Pyrimidines - metabolism; Rats; Rats, Wistar; Research Article; Solubility; Suspensions; X-Ray Diffraction - methods; Damkohler number; precipitation-ultrasonication method; Box-Behnken design; re-dispersibility index; solvent anti-solvent ratio