miR-34a and miR-21 as biomarkers in evaluating the response of chemo-radiotherapy in Egyptian breast cancer patients

• Published in: Journal of Radiation Research and Applied Sciences Vol. 15; no. 3; pp. 285 - 292
• Main Authors: Shaban, Nadia Z., Ibrahim, Nashwa K., Saada, Helen N., El-Rashidy, Fatma H., Shaaban, HebatAllah M., Farrag, Mostafa A., ElDebaiky, Khaled, Kodous, Ahmad S.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.09.2022; Elsevier
• Subjects: Bcl-2; BRCA1 BRCA2; Chemo-radiotherapy; Female; miR-21; miR-34a; P53 breast cancer; Bcl-2; P53 breast cancer; BRCA1 BRCA2; miR-34a; Female; miR-21; Chemo-radiotherapy

MiRNA-21 (miR-21) promotes the initiation and progression of tumor by initiating cell cycle differentiation, while miR-34a induces apoptosis through activating the tumor-suppressor gene p53, and by repressing the anti-apoptotic protein, B-cell lymphoma 2 (Bcl2). To investigate if the expression fold...