Neurobiological mechanisms and therapeutic impact of electroconvulsive therapy (ECT)

Electroconvulsive therapy (ECT) is an efficient therapeutic resource for psycho-pharmacotherapeutic resistant forms of depression. ECT is a form of electrical brain stimulation involving the induction of a controlled seizure, clinically similar to an epileptic seizure, that is initiated in the prefr...

Full description

Saved in:
Bibliographic Details
Published inRomanian journal of morphology and embryology Vol. 65; no. 1; pp. 13 - 17
Main Authors Cojocaru, Ana Maria, Vasile, Antonia Ioana, Trifu, Simona Corina
Format Journal Article
LanguageEnglish
Published Romania Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 01.01.2024
Subjects
Brain
Electroconvulsive Therapy
Humans
Neurobiology
Review
Seizures - therapy
Online AccessGet full text

Cover

Abstract Electroconvulsive therapy (ECT) is an efficient therapeutic resource for psycho-pharmacotherapeutic resistant forms of depression. ECT is a form of electrical brain stimulation involving the induction of a controlled seizure, clinically similar to an epileptic seizure, that is initiated in the prefrontal region of the brain and spreads to the cortex and subcortex, including the diencephalic structures. This is achieved by creating a transcranial electric field and synchronously depolarizing neuronal membranes. The mechanisms of action of ECT are not yet fully understood, but several hypotheses have been proposed to explain how it affects the brain: neurotransmitter changes, neuroplasticity, network connectivity, endocrine system regulation and changes in regional cerebral blood flow and regional metabolism.
AbstractList Electroconvulsive therapy (ECT) is an efficient therapeutic resource for psycho-pharmacotherapeutic resistant forms of depression. ECT is a form of electrical brain stimulation involving the induction of a controlled seizure, clinically similar to an epileptic seizure, that is initiated in the prefrontal region of the brain and spreads to the cortex and subcortex, including the diencephalic structures. This is achieved by creating a transcranial electric field and synchronously depolarizing neuronal membranes. The mechanisms of action of ECT are not yet fully understood, but several hypotheses have been proposed to explain how it affects the brain: neurotransmitter changes, neuroplasticity, network connectivity, endocrine system regulation and changes in regional cerebral blood flow and regional metabolism.
Author Trifu, Simona Corina
Vasile, Antonia Ioana
Cojocaru, Ana Maria
AuthorAffiliation 2 Doctoral School, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
1 Department of Psychiatry, Prof. Dr. Alexandru Obregia Clinical Hospital for Psychiatry, Bucharest, Romania
3 Department of Neurosciences, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
AuthorAffiliation_xml – name: 1 Department of Psychiatry, Prof. Dr. Alexandru Obregia Clinical Hospital for Psychiatry, Bucharest, Romania
– name: 2 Doctoral School, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
– name: 3 Department of Neurosciences, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Author_xml – sequence: 1
  givenname: Ana Maria
  surname: Cojocaru
  fullname: Cojocaru, Ana Maria
  email: antoniaioana97.vasile@gmail.com
  organization: Doctoral School, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; antoniaioana97.vasile@gmail.com
– sequence: 2
  givenname: Antonia Ioana
  surname: Vasile
  fullname: Vasile, Antonia Ioana
– sequence: 3
  givenname: Simona Corina
  surname: Trifu
  fullname: Trifu, Simona Corina
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38527979$$D View this record in MEDLINE/PubMed
BookMark eNpVkMtLw0AQxhep2Fp79Co56iFxX9lNTiKlvqgKUs_LZjvbriTZkEeh_72prUXnMvDNb75hvnM0KH0JCF0SHHFJBL39eHmdRSKOSITpCRpRLESYUJkO0IhQikMcUzpEk6b5wn0JHGMmz9CQJXEPyXSEFm_Q1T5zPvcrZ3QeFGDWunRN0QS6XAbtGmpdQdc6E7ii0qYNvA0gB9PW3vhy0-WN28CB2wbXs-ni5gKdWp03MDn0Mfp8mC2mT-H8_fF5ej8PDeO8DUFyZq3NZJYYIyChwGMupZGGG82YodpKmWaMacF1nAKzS9gpemmgf9SyMbrb-1ZdVkCvlm2tc1XVrtD1Vnnt1P9J6dZq5TeKEMIF78MYo3DvYGrfNDXY4zLB6iditYtYiVgRhWnPX_29eKR_A2XfQHl8Hw
ContentType Journal Article
Copyright Copyright © 2024, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2024
Copyright_xml – notice: Copyright © 2024, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2024
CorporateAuthor Doctoral School, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Psychiatry, Prof. Dr. Alexandru Obregia Clinical Hospital for Psychiatry, Bucharest, Romania; Doctoral School, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Psychiatry, Prof. Dr. Alexandru Obregia Clinical Hospital for Psychiatry, Bucharest, Romania; Doctoral School, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Department of Neurosciences, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
CorporateAuthor_xml – name: Department of Psychiatry, Prof. Dr. Alexandru Obregia Clinical Hospital for Psychiatry, Bucharest, Romania; Doctoral School, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Department of Neurosciences, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
– name: Doctoral School, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
– name: Department of Psychiatry, Prof. Dr. Alexandru Obregia Clinical Hospital for Psychiatry, Bucharest, Romania; Doctoral School, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
5PM
DOI 10.47162/RJME.65.1.02
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
DatabaseTitleList
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
EISSN 2066-8279
EndPage 17
ExternalDocumentID 10_47162_RJME_65_1_02
38527979
Genre Journal Article
GroupedDBID CGR
CUY
CVF
ECM
EIF
NPM
---
123
AAKDD
AAYXX
ADBBV
AENEX
ALMA_UNASSIGNED_HOLDINGS
BAWUL
CITATION
DIK
EBD
EMOBN
EOJEC
F5P
OBODZ
OK1
PGMZT
RPM
SV3
TR2
5PM
ID FETCH-LOGICAL-c344t-e743fffb7b8cc6e82e45477c7c4ca33c2af779b33a64a59e3fdef779adce066f3
IEDL.DBID RPM
ISSN 1220-0522
IngestDate Tue Sep 17 21:28:20 EDT 2024
Fri Aug 23 01:46:12 EDT 2024
Tue Oct 29 09:12:11 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Issue 1
Language English
License This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c344t-e743fffb7b8cc6e82e45477c7c4ca33c2af779b33a64a59e3fdef779adce066f3
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146450/
PMID 38527979
PageCount 5
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_11146450
crossref_primary_10_47162_RJME_65_1_02
pubmed_primary_38527979
PublicationCentury 2000
PublicationDate 2024-01-01
PublicationDateYYYYMMDD 2024-01-01
PublicationDate_xml – month: 01
  year: 2024
  text: 2024-01-01
  day: 01
PublicationDecade 2020
PublicationPlace Romania
PublicationPlace_xml – name: Romania
PublicationTitle Romanian journal of morphology and embryology
PublicationTitleAlternate Rom J Morphol Embryol
PublicationYear 2024
Publisher Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest
Publisher_xml – name: Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest
SSID ssj0000605037
Score 1.958465
Snippet Electroconvulsive therapy (ECT) is an efficient therapeutic resource for psycho-pharmacotherapeutic resistant forms of depression. ECT is a form of electrical...
SourceID pubmedcentral
crossref
pubmed
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 13
SubjectTerms Brain
Electroconvulsive Therapy
Humans
Neurobiology
Review
Seizures - therapy
Title Neurobiological mechanisms and therapeutic impact of electroconvulsive therapy (ECT)
URI https://www.ncbi.nlm.nih.gov/pubmed/38527979
https://pubmed.ncbi.nlm.nih.gov/PMC11146450
Volume 65
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La8JAEB7UQ_FSWvqyD9lDKe0hJu4jmxyLKCJEpCh4C5vNLhVMlKqH_vvu5iF67TWZQPLtkplJvu8bgNdACjvTNnUITgKHmoLCEcRPHF_zlAumQlko5KKpP17QyZItG-DXWpiCtC-TVS9fZ7189V1wK7eZdGuemDuLBn0rpaXMc5vQNDv0pEcv37_W46SYqoKx_dOLcWmuSa1bkvs1iYY9n_WsV2cbLkjAMA8tk-skLx2T0TlR8iTzjK7gsioZ0Wd5a9fQUPkNzAtXjdJCyeKMMmU1vKtdtkMiT9GJrgqVSki00agaemOp5oe1Ja5Xcb_ofTiYf9zCYjScD8ZONSHBkYTSvaNM_tdaJzwJpPRVgJX15-KSSyoFIRILzXmYECJ8KlioiE6VPSLME5laQ5M7aOWbXD0A8jxNA41TZhoYKlRfJEx5QSixwilVmHfgrcYn3pZGGLFpIApMY4tp7LO4H3u4A_claMewGuIOBGdwHgOsxfX5GbPyhdV1vdKP_7_0CdrYFCLlZ5NnaO1_DurFFBL7pAvN6SzqFrvnD8rLym4
link.rule.ids 230,315,730,783,787,888,27938,27939,53806,53808
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9pAEB6lRGpzaVL1EZpH91BV7cHG7NM-RghEKKCqIio3a3e9q6KAiRo4NL8-u16MILfk6h1L9ny2Z8b7zTcAX1Mt_UzbIiJYpRF1CUUkCVcRt6IQkplMVx1yozHv39DBlE0PgNe9MBVpX6tZXM4XcTn7W3Er7xa6VfPEWr9GnbZvpaUsab2CQ_fCJnynSg9fYK9yUs1Vwdjv9WIc5DWp10tq_R6MujFnsVfrPILXJGVYZJ7LtROZtuFonyq5E3t6x_CnvupAObmN1ysV64cngo7Pv60TeLtJR9FVWH8HB6Z8D5NKsSPIM3kM0cL4_uDZ_eIeybJAOz1bKHRZoqVFm4E6nsa-nntS_MbuP_re7Ux-fICbXnfS6Ueb6QuRJpSuIuNyC2utEirVmpsUG6_9JbTQVEtCNJZWiEwRIjmVLDPEFsYfkc5XLo-x5CM0ymVpTgEliaWpxQVzxRGVpi0VM0maaWxwQQ0WTfhWez6_CyIbuStOKrRyj1bOWd7OE9yETwGOrVkNXhPSPaC2Bl4-e3_Fub-S0a7d_fnlp36BN_3JaJgPr8c_z-AIu4Qn_J45h8bq39pcuIRlpS6rp_MRx1PrgQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9tAEB1RkBCXFgS0aWnZA0Jw8Ef2w7s-ViERX0EIBQmJg7W73lWjEhM1yaH99ex67Sjpkas9lux9tueN_eYNwInQ0s-0LSOClYioIxSRJJmKMstLLpnJdd0hN7zLLh_p9RN7alSVs0ZWWWk1jquXSVyNf9XayulEJ61OLLkf9rq-lZayNJmWNvkAW-6hTcVKpR7ewt7ppJ6tgrH_34txsNik3jMpebge9uOMxd6xcwe2iWCY517PtZKdlilpXS65kn8Gn-C5PfMgO_kdL-Yq1v_-M3V836XtwseGlqKfIWYPNky1D6PauSPYNHks0cT4PuHxbDJDsirRSu8WCt2W6NWiZrCOl7MvXrw4von7i876vdH5ATwO-qPeZdRMYYg0oXQeGccxrLWKK6F1ZgQ23gOMa66ploRoLC3nuSJEZlSy3BBbGr9FuvVyfMaSQ9isXivzBVCaWiosLpkrkqg0XamYSUWuscElNZh34LRd_WIazDYKV6TUiBUesSJjRbdIcQc-B0iWYS2AHRBrYC0DvI32-h4HQW2n3S751_cfegzb9xeD4vbq7uYb7GDHe8JXmiPYnP9ZmO-Ot8zVj_oGfQMtJe4B
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Neurobiological+mechanisms+and+therapeutic+impact+of+electroconvulsive+therapy+%28ECT%29&rft.jtitle=Romanian+journal+of+morphology+and+embryology&rft.au=Cojocaru%2C+Ana-Maria&rft.au=Vasile%2C+Antonia+Ioana&rft.au=Trifu%2C+Simona+Corina&rft.date=2024-01-01&rft.pub=Academy+of+Medical+Sciences%2C+Romanian+Academy+Publishing+House%2C+Bucharest&rft.issn=1220-0522&rft.eissn=2066-8279&rft.volume=65&rft.issue=1&rft.spage=13&rft.epage=17&rft_id=info:doi/10.47162%2FRJME.65.1.02&rft_id=info%3Apmid%2F38527979&rft.externalDBID=PMC11146450
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1220-0522&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1220-0522&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1220-0522&client=summon