Mechanism underlying early anaemia in children with familial juvenile nephronophthisis

• Published in: Pediatric nephrology (Berlin, West) Vol. 10; no. 5; pp. 578 - 581
• Main Authors: ALA-MELLO, S, KIVIVUORI, S. M, RÖNNHOLM, K. A. R, KOSKIMIES, O, SIIMES, M. A
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.10.1996; Springer Nature B.V
• Subjects: Adolescent; Anemia - etiology; Biological and medical sciences; Child; Erythropoietin - blood; Female; Humans; Iron - metabolism; Male; Medical sciences; Nephritis, Interstitial - complications; Nephritis, Interstitial - genetics; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Tubulopathies; Human; Urinary system disease; Erythropoietin; Anemia; Pathogenesis; Renal disease; Hemopathy; Hereditary; Metabolism; Iron ion; Tubulointerstitial nephritis; Complication; Child; Biological receptor

Familial juvenile nephronophthisis (NPH) is a hereditary form of chronic tubulointerstitial nephritis with onset in childhood. About one-third of patients develop anaemia before renal insufficiency. We investigated the pathogenetic mechanisms leading to anaemia by comparing 6 patients with NPH and 1...