Fabrication of targeted gold nanoparticle as potential contrast agent in molecular CT imaging
Trastuzumab (TZ) multifunctional Fe3O4 coated gold nanoparticles (Au NPs) through polyethylene glycol (PEG) linking for targeted molecular computed tomography (CT) imaging was developed. The prepared TZ-PEG-Fe3O4@Au NPs were fully characterized and cytocompatibility, X-ray attenuation measurement, a...
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| Published in | Journal of radiation research and applied sciences Vol. 16; no. 1; p. 100490 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
01.03.2023
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1687-8507 1687-8507 |
| DOI | 10.1016/j.jrras.2022.100490 |
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| Abstract | Trastuzumab (TZ) multifunctional Fe3O4 coated gold nanoparticles (Au NPs) through polyethylene glycol (PEG) linking for targeted molecular computed tomography (CT) imaging was developed. The prepared TZ-PEG-Fe3O4@Au NPs were fully characterized and cytocompatibility, X-ray attenuation measurement, and in vitro cell targeting ability were analyzed. The findings showed that the synthesized NPs, with a size of less than 100 nm, were non-toxic at specific concentration ranges, and exhibit better X-ray attenuation intensity than iodine-based contrast agents at the same concentration. The created targeted NPs can be employed as a contrast agent for molecular targeted CT imaging of cancer cells expressing the human epidermal growth factor receptor 2 (HER-2). |
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| AbstractList | Trastuzumab (TZ) multifunctional Fe3O4 coated gold nanoparticles (Au NPs) through polyethylene glycol (PEG) linking for targeted molecular computed tomography (CT) imaging was developed. The prepared TZ-PEG-Fe3O4@Au NPs were fully characterized and cytocompatibility, X-ray attenuation measurement, and in vitro cell targeting ability were analyzed. The findings showed that the synthesized NPs, with a size of less than 100 nm, were non-toxic at specific concentration ranges, and exhibit better X-ray attenuation intensity than iodine-based contrast agents at the same concentration. The created targeted NPs can be employed as a contrast agent for molecular targeted CT imaging of cancer cells expressing the human epidermal growth factor receptor 2 (HER-2). |
| ArticleNumber | 100490 |
| Author | Abdollahi, Behnaz Babaye Ghorbani, Marjan Faghani, Parsa Mortezazadeh, Tohid Malekzadeh, Reza Farhood, Bagher |
| Author_xml | – sequence: 1 givenname: Reza surname: Malekzadeh fullname: Malekzadeh, Reza organization: Department of Medical Physics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 2 givenname: Marjan surname: Ghorbani fullname: Ghorbani, Marjan organization: Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 3 givenname: Parsa surname: Faghani fullname: Faghani, Parsa organization: Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran – sequence: 4 givenname: Behnaz Babaye surname: Abdollahi fullname: Abdollahi, Behnaz Babaye organization: Department of Medical Physics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 5 givenname: Tohid surname: Mortezazadeh fullname: Mortezazadeh, Tohid email: tmortezazadeh@yahoo.com organization: Department of Medical Physics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 6 givenname: Bagher surname: Farhood fullname: Farhood, Bagher email: bffarhood@gmail.cm, farhood-b@kaums.ac.ir organization: Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran |
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| CitedBy_id | crossref_primary_10_1021_acs_nanolett_4c05641 crossref_primary_10_5802_crchim_348 crossref_primary_10_1002_wnan_70004 crossref_primary_10_1016_j_mtchem_2024_102233 crossref_primary_10_15625_2525_2518_19457 crossref_primary_10_1063_5_0231279 crossref_primary_10_1007_s10544_024_00725_y crossref_primary_10_1016_j_envres_2023_116526 crossref_primary_10_1007_s11696_024_03315_7 crossref_primary_10_4028_p_5lOBa0 crossref_primary_10_1007_s10876_024_02724_8 crossref_primary_10_1016_j_radphyschem_2024_112195 |
| Cites_doi | 10.1016/j.radphyschem.2022.110147 10.1021/la302446h 10.1039/C5RA13838H 10.1016/j.apsusc.2017.03.200 10.1111/jmi.12013 10.1038/srep05020 10.1021/am201311c 10.1007/s00411-020-00865-8 10.1007/s00330-010-1768-9 10.1118/1.594357 10.1016/j.ijbiomac.2018.01.159 10.1016/j.carbpol.2020.117262 10.1016/j.mtcomm.2020.101368 10.1021/acs.bioconjchem.7b00194 10.1039/C7NR01153A 10.1088/0031-9155/58/6/1683 10.1088/0957-4484/17/3/004 10.2217/nnm.14.171 10.1200/JCO.2007.14.3065 10.1016/j.jmmm.2014.09.060 10.1016/j.cej.2007.07.068 10.4172/2157-7439.1000115 10.1021/nn200809t 10.2217/nnm.15.166 10.1007/s11051-015-3097-z |
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| Keywords | Molecular CT imaging Gold nanoparticles Trastuzumab Contrast agent Cancer |
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| SubjectTerms | Cancer Contrast agent Gold nanoparticles Molecular CT imaging Trastuzumab |
| Title | Fabrication of targeted gold nanoparticle as potential contrast agent in molecular CT imaging |
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