Involvement of serotonin 5-HT3 receptors in the modulation of noradrenergic transmission by serotonin reuptake inhibitors: a microdialysis study in rat brain

• Published in: Psychopharmacology Vol. 229; no. 2; pp. 331 - 344
• Main Authors: Fernández-Pastor, Begoña, Ortega, Jorge E., Meana, J. Javier
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2013
• Subjects: Analysis of Variance; Animals; Area Under Curve; Biomedical and Life Sciences; Biomedicine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Isoquinolines - pharmacology; Locus Coeruleus - drug effects; Locus Coeruleus - metabolism; Male; Microdialysis; Naphthyridines - pharmacology; Neurosciences; Norepinephrine - metabolism; Original Investigation; Pharmacology/Toxicology; Prefrontal Cortex - drug effects; Prefrontal Cortex - metabolism; Psychiatry; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT3 - metabolism; Serotonin Agents - pharmacology; Wakefulness; Microdialysis; SSRIs; receptors; Antidepressants; Prefrontal cortex; 5-HT; Noradrenaline; Locus coeruleus; Citalopram

Rationale Selective serotonin reuptake inhibitors (SSRIs), in addition to being able to enhance serotonergic neurotransmission, are able to modulate other brain systems involved in depression. Objectives This study evaluates the neurochemical effect of the SSRI citalopram on brain noradrenergic acti...