Metabolism-Dependent Inhibition of CYP3A4 by Lapatinib: Evidence for Formation of a Metabolic Intermediate Complex with a Nitroso/Oxime Metabolite Formed via a Nitrone Intermediate - Barbara, Joanna E.; Kazmi, Faraz; Parkinson, Andrew; Buckley, David B. (Drug metabolism and disposition, 2013)
Keywords: Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors - pharmacology; Humans; Lapatinib; Mass Spectrometry; Microsomes, Liver - metabolism; Nitrogen Oxides - metabolism; Oximes - metabolism; Quinazolines - pharmacology; MDI; LC; DDI; HLM; P450; MI; MS/MS; MSE