Tetraphenylethylene-doped covalent organic frameworks as a highly efficient aggregation-induced electrochemiluminescence emitter for ultrasensitive miRNA-21 analysis
MicroRNAs (miRNAs) as a well-known kind of cancer marker are closely associated with the formation and metastasis of tumors. Here, a novel tetraphenylethylene (TPE)-doped covalent organic frameworks (TPE-COFs) with strong aggregation-induced electrochemiluminescence (AIECL) response was synthesized...
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| Published in | Advanced Sensor and Energy Materials Vol. 2; no. 2; p. 100059 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
01.06.2023
Elsevier |
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| Online Access | Get full text |
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| Abstract | MicroRNAs (miRNAs) as a well-known kind of cancer marker are closely associated with the formation and metastasis of tumors. Here, a novel tetraphenylethylene (TPE)-doped covalent organic frameworks (TPE-COFs) with strong aggregation-induced electrochemiluminescence (AIECL) response was synthesized and introduced to construct an ultrasensitive biosensor for the detection of miRNA-21. The strong aggregation-induced emission (AIE) response was obtained because the molecular motion of TPE was restricted by COFs which had the porosity and highly ordered topological structure. Meanwhile, the porous structure of COFs allowed TPE to react with electrochemiluminescence (ECL) coreactants more effectively. Furthermore, COFs significantly improved the electron transport efficiency of the entire ECL system. All of these endowed the TPE-COFs with superior AIECL performance. Then, a TPE-COFs based ECL resonance energy transfer (ECL-RET) system was constructed for ultrasensitive miRNA-21 biosensing with differential signal readout. The proposed assays exhibited excellent sensitivity with a wide dynamic range from 10 aM to 1 pM and a low detection limit of 2.18 aM. Therefore, these indicated that doping TPE in COFs was a creative way to develop functional COFs and provided an effective way for enhancing AIECL. Furthermore, this work boarded the application of AIECL in analytical chemistry. |
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| AbstractList | MicroRNAs (miRNAs) as a well-known kind of cancer marker are closely associated with the formation and metastasis of tumors. Here, a novel tetraphenylethylene (TPE)-doped covalent organic frameworks (TPE-COFs) with strong aggregation-induced electrochemiluminescence (AIECL) response was synthesized and introduced to construct an ultrasensitive biosensor for the detection of miRNA-21. The strong aggregation-induced emission (AIE) response was obtained because the molecular motion of TPE was restricted by COFs which had the porosity and highly ordered topological structure. Meanwhile, the porous structure of COFs allowed TPE to react with electrochemiluminescence (ECL) coreactants more effectively. Furthermore, COFs significantly improved the electron transport efficiency of the entire ECL system. All of these endowed the TPE-COFs with superior AIECL performance. Then, a TPE-COFs based ECL resonance energy transfer (ECL-RET) system was constructed for ultrasensitive miRNA-21 biosensing with differential signal readout. The proposed assays exhibited excellent sensitivity with a wide dynamic range from 10 aM to 1 pM and a low detection limit of 2.18 aM. Therefore, these indicated that doping TPE in COFs was a creative way to develop functional COFs and provided an effective way for enhancing AIECL. Furthermore, this work boarded the application of AIECL in analytical chemistry. |
| ArticleNumber | 100059 |
| Author | Wang, Shengfu Shu, Wen-Yi Yao, Linli Xiong, Chengyi Xiao, Yao Su, Ruiqi Chen, Miao-Miao Wen, Wei Zhang, Xiuhua |
| Author_xml | – sequence: 1 givenname: Wen-Yi surname: Shu fullname: Shu, Wen-Yi organization: Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China – sequence: 2 givenname: Ruiqi surname: Su fullname: Su, Ruiqi organization: Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China – sequence: 3 givenname: Linli surname: Yao fullname: Yao, Linli organization: Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China – sequence: 4 givenname: Yao surname: Xiao fullname: Xiao, Yao organization: Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China – sequence: 5 givenname: Miao-Miao surname: Chen fullname: Chen, Miao-Miao organization: Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China – sequence: 6 givenname: Wei surname: Wen fullname: Wen, Wei organization: Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China – sequence: 7 givenname: Shengfu surname: Wang fullname: Wang, Shengfu organization: Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China – sequence: 8 givenname: Chengyi orcidid: 0000-0003-3285-0934 surname: Xiong fullname: Xiong, Chengyi email: xiongchengyi@hubu.edu.cn organization: Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China – sequence: 9 givenname: Xiuhua surname: Zhang fullname: Zhang, Xiuhua email: zhangxh@hubu.edu.cn organization: Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China |
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| Keywords | Covalent organic frameworks Resonance energy transfer MicroRNA-21 Aggregation-induced electrochemiluminescence Biosensor |
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| Title | Tetraphenylethylene-doped covalent organic frameworks as a highly efficient aggregation-induced electrochemiluminescence emitter for ultrasensitive miRNA-21 analysis |
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