Translational Pharmacokinetic Modeling of Fingolimod (FTY720) as a Paradigm Compound Subject to Sphingosine Kinase-Mediated Phosphorylation - Snelder, Nelleke; Ploeger, Bart A.; Luttringer, Olivier; Stanski, Donald. R.; Danhof, Meindert (Drug metabolism and disposition, 2014)
Keywords: Administration, Intravenous; Administration, Oral; Animals; Blood Platelets - metabolism; Double-Blind Method; Fingolimod Hydrochloride; Humans; Lysophospholipids - metabolism; Male; Phosphates - metabolism; Phosphorylation - drug effects; Phosphotransferases (Alcohol Group Acceptor) - metabolism; Propylene Glycols - administration & dosage; Propylene Glycols - pharmacokinetics; Randomized Controlled Trials as Topic; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Sphingosine - administration & dosage; Sphingosine - analogs & derivatives; Sphingosine - metabolism; Sphingosine - pharmacokinetics; Km; S1P; Vin vivo; fingolimod-P; ka; Vm; PBPK; Kd; PK; S1PHK; LOQ