Rotundarpene inhibits TNF-α-induced activation of the Akt, mTOR, and NF-κB pathways, and the JNK and p38 associated with production of reactive oxygen species

• Published in: Molecular and cellular biochemistry Vol. 434; no. 1-2; pp. 113 - 125
• Main Authors: Kim, Arum, Nam, Yoon Jeong, Shin, Yong Kyoo, Lee, Min Sung, Sohn, Dong Suep, Lee, Chung Soo
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2017
• Subjects: Biochemistry; Biomedical and Life Sciences; Cardiology; Life Sciences; Medical Biochemistry; Oncology; Keratinocytes; Inflammatory mediator production; JNK and p38-MAPK; Tumor necrosis factor-α; Rotundarpene; Akt, mTOR and NF-κB pathways

Ilex Rotunda Thunb has been shown to have anti-inflammatory and antioxidant effects. In human keratinocytes, we investigated the effect of rotundarpene (4-caffeoyl-3-methyl-but-2-ene-1,4-diol) on the TNF-α-stimulated production of inflammatory mediators in relation to the Akt, mTOR, and NF-κB pathwa...