ER stress and cancer: The FOXO forkhead transcription factor link

• Published in: Molecular and cellular endocrinology Vol. 462; no. Pt B; pp. 67 - 81
• Main Authors: Alasiri, Glowi, Fan, Lavender Yuen-Nam, Zona, Stefania, Goldsbrough, Isabella Galeno, Ke, Hui-Ling, Auner, Holger Werner, Lam, Eric Wing-Fai
• Format: Journal Article
• Language: English
• Published: Ireland 15.02.2018
• Subjects: Animals; Endoplasmic Reticulum Stress; Forkhead Transcription Factors - metabolism; Humans; Neoplasms - metabolism; Neoplasms - pathology; ER stress; FOXO; Forkhead transcription factors; Endoplasmic reticulum; Cancer; Unfolded protein response

The endoplasmic reticulum (ER) is a cellular organelle with central roles in maintaining proteostasis due to its involvement in protein synthesis, folding, quality control, distribution and degradation. The accumulation of misfolded proteins in the ER lumen causes 'ER stress' and threatens...