Huangqi Jianzhong decoction improves gastric intestinal metaplasia in rats by regulating the gut‒thyroid axis

• Published in: Phytomedicine (Stuttgart) Vol. 135; p. 156174
• Main Authors: Xiao, Ling, Cheng, Yu-qin, Ma, Wen-shuo, Zhu, Wen-fei, Wu, Jian-ping, Meng, Yu-fen, Shi, Li-yun, Zhang, Wei, Chen, Lei, Cheng, Chun, Zhang, Jun-feng
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.12.2024
• Subjects: animal models; Animals; Bifidobacterium; blood serum; Butyric acid; Butyric Acid - pharmacology; cold; Cold Temperature; cold tolerance; deoxycholic acid; Disease Models, Animal; Drugs, Chinese Herbal - pharmacology; Gastric intestinal metaplasia; gastric mucosa; Gastrointestinal Microbiome - drug effects; genes; Gut microbiota‒thyroid axis; Huangqi Jianzhong decoction; Humans; intestinal microorganisms; intestines; Male; membrane potential; metabolites; metabolomics; Metaplasia; mitochondria; mitochondrial membrane; Oriental traditional medicine; p-cresol; Rats; Rats, Sprague-Dawley; reactive oxygen species; salicylic acid; stomach neoplasms; sulfates; Temperature‒tropism behavior; therapeutics; thyroid function; Thyroid Gland - drug effects; Gastric intestinal metaplasia; Huangqi Jianzhong decoction; Gut microbiota‒thyroid axis; Temperature‒tropism behavior; Butyric acid

•GIM rats exhibited gastro-thyroid comorbidities with cold-intolerant. HQJZ treatment restored low-temperature-tropism behavior, enriching fecal butyrate-producing bacteria, and improved thyroid tissue lesions.•In vivo and in vitro experiments proved that butyrate improved thyroid tissue lesions, en...