The surgical and clinicopathological characteristics of primary mucinous ovarian cancer: a single institution 30-year retrospective analysis

• Published in: Journal of the Turkish German Gynecological Association Vol. 24; no. 4; pp. 252 - 260
• Main Authors: Aytekin, Okan, Yüksel, Dilek, Oktar, Okan, Çakır, Caner, Kimyon Cömert, Günsu, Korkmaz, Vakkas, Engin-Üstün, Yaprak, Turan, Taner
• Format: Journal Article
• Language: English
• Published: Turkey Galenos Publishing House 01.12.2023
• Subjects: Abdomen; Chemotherapy; Fertility; Gynecology; Health sciences; Hospitals; Magnetic resonance imaging; Medical prognosis; Metastasis; Multivariate analysis; Obstetrics; Oncology; Ovarian cancer; Pathology; Patients; Statistical analysis; Surgery; Tomography; Tumors; Womens health; platinum-based chemotherapy; Mucinous ovarian carcinoma; stage; treatment response; survival
• ISSN: 1309-0399; 1309-0380
• DOI: 10.4274/jtgga.galenos.2023.2022-8-1

To evaluate the clinicopathological characteristics of primary mucinous ovarian carcinoma (MOC) and define oncologic outcomes. This retrospective study reviewed patients diagnosed with primary MOC at a single institution and underwent primary treatment between 1990 and 2019. The clinicopathological factors affecting oncological outcomes and treatment response were evaluated. The Kaplan-Meier method was used to evaluate survival outcomes. Survival curves were compared using the log-rank test. The cohort's (n=92) median (range) age was 48 (15-82) years. Seventy-five (81.5%) patients were in the International Federation of Gynecology and Obstetrics stage I-II. Forty patients received platinum-based adjuvant chemotherapy. The 5-year progression-free survival was 98% in stage I-II and 17% for stage III-IV (p<0.001). In multivariate analysis, the only independent risk factor for disease failure was stage (hazard ratio: 6.838, 95% confidence interval: 1,358-34,415; p=0.020). Advanced stage was an independent poor prognostic factor for recurrence in patient with MOC.