Examining Small Intestinal Transit Time as a Function of Age: Is There Evidence to Support Age-Dependent Differences among Children?

• Published in: Drug metabolism and disposition Vol. 44; no. 7; pp. 1080 - 1089
• Main Authors: Maharaj, Anil R, Edginton, Andrea N
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2016
• Subjects: Administration, Oral; Adolescent; Adult; Age Factors; Aging; Child; Delayed-Action Preparations; Gastrointestinal Transit; Humans; Intestinal Absorption; Intestine, Small; Linear Models; Models, Biological; Nonlinear Dynamics; Theophylline - administration & dosage; Theophylline - pharmacokinetics; OCTT; SITT; GI; PBPK; H2; PK; LITT; SR

The small intestine represents the region where the majority of drug and nutrient absorption transpires. Among adults, small intestinal transit kinetics is well delineated; however, the applicability of these values toward children remains unclear. This article serves to examine the relationship bet...