Design and evaluation of matrix base with sigmoidal release profile for colon-specific delivery using a combination of Eudragit and non-ionic cellulose ether polymers

• Published in: Drug delivery and translational research Vol. 1; no. 2; pp. 132 - 146
• Main Authors: Asghar, Laila Fatima Ali, Chandran, Sajeev
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.04.2011
• Subjects: Biomedical and Life Sciences; Biomedicine; Pharmaceutical Sciences/Technology; Research Article; Controlled release; Colonic drug delivery; Scintigraphy

A pH- and time-controlled drug delivery system with sigmoidal release profile was developed using Eudragit (L100 or S100) in combination with hydroxy ethyl cellulose (HEC) or hydroxy propyl cellulose (HPC) for sigmoidal release of indomethacin in the potential treatment of colon cancer. The effect o...