Prognostic impact of incisional or excisional biopsy of cervical lymph node metastases of solid tumors

• Published in: Japanese journal of clinical oncology Vol. 48; no. 6; pp. 529 - 534
• Main Authors: Shinohara, Shogo, Takebayashi, Shinji, Kikuchi, Masahiro, Michida, Tetsuhiko, Hayashi, Kazuki, Yamamoto, Ryosuke, Saida, Koji, Mizuno, Keisuke, Fujiwara, Keizo, Naito, Yasushi
• Format: Journal Article
• Language: English
• Published: England 01.06.2018
• Subjects: Adult; Aged; Aged, 80 and over; Animals; Biopsy; Cervical Vertebrae - pathology; Chick Embryo; Female; Humans; Kaplan-Meier Estimate; Lymph Nodes - pathology; Lymphatic Metastasis - pathology; Male; Middle Aged; Neoplasms - pathology; Prognosis; Retrospective Studies; Survival Rate
• ISSN: 1465-3621; 1465-3621
• DOI: 10.1093/jjco/hyy056

In performing an open biopsy of a neck mass, an incisional biopsy may increase the risk of cancer cell seeding and dissemination that, ultimately, worsens a patient's survival. The aim of this study was to compare the impact of incisional and excisional biopsies of cervical lymph node metastases of solid tumors on patients' survival. A retrospective review was made of patients with cervical metastases of solid tumors who underwent an open biopsy for a diagnosis between 2005 and 2015. Sixty-four patients met the criteria out of 524 open biopsy cases undertaken during the period. Survival analyses were estimated from 33 cases whose initial symptoms were the presence of a neck mass, using two modes of biopsy: excisional and incisional. The 2-year overall survival rates in incisional and excisional biopsy groups were 65% and 43%, respectively, and 2-year disease-specific survival rates were 74% and 43%, respectively. The differences were not significant. For lung cancer or head and neck cancer subgroups, survival differences between incisional and excisional biopsy groups were also not significant. A carefully targeted physical examination and performing a fine needle aspiration are essential to establish a diagnosis for the etiology of an unknown neck mass. In performing an open biopsy, the effect of an incisional biopsy on patients' survival was no worse than that of an excisional biopsy, despite the latter being theoretically preferable.