High-sensitivity imaging of time-domain near-infrared light transducer

• Published in: Nature photonics Vol. 13; no. 8; pp. 525 - 531
• Main Authors: Gu, Yuyang, Guo, Zhiyong, Yuan, Wei, Kong, Mengya, Liu, Yulai, Liu, Yongtao, Gao, Yilin, Feng, Wei, Wang, Fan, Zhou, Jiajia, Jin, Dayong, Li, Fuyou
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2019; Nature Publishing Group
• Subjects: 639/301/357/354; 639/624/1107/510; 639/624/1111/55; 639/925/930/2735; Applied and Technical Physics; Bearing (direction); Biocompatibility; Contrast agents; Contrast media; Dosage; Efficiency; Emission; Emissions; Energy; Excitation spectra; Fluorescence; I.R. radiation; Infrared imaging; Infrared windows; Letter; Lifetime; Medical imaging; Nanocrystals; Nanomaterials; Nanoparticles; Near infrared radiation; Optics; Organs; Photonics; Physics; Quantum dots; Quantum Physics; Short pulses; Signal to noise ratio; Time domain analysis; Transducers; Tumors; Upconversion; Windows (intervals); Ytterbium

The optically transparent biological window in the near-infrared (NIR) spectral range allows deep-tissue excitation and the detection of fluorescence signals 1 , 2 . Spectrum-domain discrimination of NIR contrast agents via an upconversion or downshifting scheme requires sufficient (anti-) Stokes sh...