Melatonin augments expression of the procollagen α1 (I) and α1 (III) genes in the infarcted heart scar of pinealectomized rats

• Published in: Connective tissue research Vol. 51; no. 6; pp. 491 - 496
• Main Authors: Drobnik, Jacek, Olczak, S awomir, Owczarek, Katarzyna, Hrabec, Zbigniew, Hrabec, El bieta
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.12.2010; Taylor & Francis
• Subjects: Animals; cell cultures; Cells, Cultured; Cicatrix - drug therapy; Cicatrix - metabolism; Cicatrix - pathology; Collagen Type I - biosynthesis; Collagen Type I - genetics; Collagen Type III - biosynthesis; Collagen Type III - genetics; connective tissue; Disease Models, Animal; healing; Male; Melatonin - administration & dosage; Melatonin - physiology; myocardial infarction; Myocardial Infarction - drug therapy; Myocardial Infarction - metabolism; Myocardial Infarction - pathology; Myofibroblasts - cytology; Myofibroblasts - drug effects; Myofibroblasts - metabolism; pineal gland; Pineal Gland - physiology; Pineal Gland - surgery; Procollagen - biosynthesis; Procollagen - genetics; Rats; Rats, Wistar; Up-Regulation - genetics

The pineal gland is involved in the regulation of collagen accumulation in peripheral wounds and scars of the infarcted heart. This study is aimed to provide an explanation of whether the pineal gland and melatonin (MLT) is involved in the regulation of α1 (I) and α1 (III) procollagen gene expressio...