Potential of Lipid Nanoparticles (SLNs and NLCs) in Enhancing Oral Bioavailability of Drugs with Poor Intestinal Permeability

• Published in: AAPS PharmSciTech Vol. 20; no. 3; p. 121
• Main Authors: Talegaonkar, Sushama, Bhattacharyya, Arundhati
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2019
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Pharmacology/Toxicology; Pharmacy; Review Article; Theme: Lipid-Based Drug Delivery Strategies for Oral Drug Delivery; toxicity; nanoparticles; SLN; NLC; permeability; oral bioavailability; lipid

Lipid-based drug delivery systems has become a popular choice for oral delivery of lipophilic drugs with dissolution rate limited oral absorption. Lipids are known to enhance oral bioavailability of poorly water-soluble drugs in multiple ways like facilitating dissolution as micellar solution, enhan...