Enhancement of Oral Bioavailability and Anti-hyperuricemic Activity of Isoliquiritigenin via Self-Microemulsifying Drug Delivery System

• Published in: AAPS PharmSciTech Vol. 20; no. 5; p. 218
• Main Authors: Zhang, Kangyi, Wang, Qilong, Yang, Qiuxuan, Wei, Qiuyu, Man, Na, Adu-Frimpong, Michael, Toreniyazov, Elmurat, Ji, Hao, Yu, Jiangnan, Xu, Ximing
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.07.2019
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Pharmacology/Toxicology; Pharmacy; Research Article; Theme: Lipid-Based Drug Delivery Strategies for Oral Drug Delivery; anti-hyperuricemic; Isoliquiritigenin; ISL-SMEDDS; bioavailability; release; in vitro release

The aim of this study was to develop a self-microemulsifying drug delivery system (SMEDDS) for enhancement of the oral bioavailability of isoliquiritigenin (ISL) as well as evaluate its in vivo anti-hyperuricemic effect in rats. The ISL-loaded self-microemulsifying drug delivery system (ISL-SMEDDS)...