Comparison of In Vitro Stereoselective Metabolism of Bupropion in Human, Monkey, Rat, and Mouse Liver Microsomes

• Published in: European journal of drug metabolism and pharmacokinetics Vol. 44; no. 2; pp. 261 - 274
• Main Authors: Bhattacharya, Chandrali, Kirby, Danielle, Van Stipdonk, Michael, Stratford, Robert E.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2019
• Subjects: Biomedical and Life Sciences; Biomedicine; Human Physiology; Medical Biochemistry; Original Research Article; Pharmaceutical Sciences/Technology; Pharmacology/Toxicology; Pharmacy

Background and Objectives Bupropion is an atypical antidepressant and smoking cessation aid associated with wide intersubject variability. This study compared the formation kinetics of three phase I metabolites (hydroxybupropion, threohydrobupropion, and erythrohydrobupropion) in human, marmoset, ra...