Systemic Hypoxia and Interventions on Nitric Oxide Metabolism Affect Retinal Vasomotion in Healthy Subjects

• Published in: Investigative ophthalmology & visual science Vol. 65; no. 14; p. 35
• Main Authors: Petersen, Line, Bek, Toke
• Format: Journal Article
• Language: English
• Published: United States The Association for Research in Vision and Ophthalmology 26.12.2024
• Subjects: Adult; Arterioles - physiology; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - pharmacology; Female; Healthy Volunteers; Humans; Hypoxia - metabolism; Hypoxia - physiopathology; Male; Middle Aged; Nitric Oxide - metabolism; Nitric Oxide Donors - pharmacology; Retina; Retinal Artery - physiology; Vasodilation - physiology; Young Adult

Previous in vitro studies on porcine retinal arterioles have shown that the frequency and amplitude of retinal vasomotion can be affected by hypoxia and nitric oxide (NO). However, it is unknown whether these effects can be reproduced in humans in vivo. Video recordings of retinal arterioles from 40...