An antibody fragment functionalized dendritic PEGylated poly(2-(dimethylamino)ethyl diacrylate) as a vehicle of exogenous microRNA

• Published in: Drug delivery and translational research Vol. 2; no. 5; pp. 406 - 414
• Main Authors: Monaghan, M., Greiser, U., Cao, H., Wang, W., Pandit, A.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.10.2012
• Subjects: Biomedical and Life Sciences; Biomedicine; Pharmaceutical Sciences/Technology; Research Article; RNA interference; Gene therapy; Antibody conjugation; Dendritic polymers; Deactivation enhanced ATRP

The translation of interfering RNA to the clinic requires more effective delivery agents to enable safe and efficient delivery. The aim of this work was to create a multi-functional delivery agent using deactivation enhanced ATRP synthesis of poly(dimethylamino)ethyl methacrylate (pDMAEMA)-co-PEGMEA...