Computational investigation into Nirematrelvir/Ritonavir synergetic efficiency compared with some approved antiviral drugs targeting main protease (Mpro) SARS-CoV-2 Omicron variant

• Published in: Journal of the Indian Chemical Society Vol. 100; no. 3; p. 100891
• Main Authors: Makhloufi, Abdesselam, Ghemit, Rima, El Kolli, Meriem, Baitiche, Milad
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.03.2023
• Subjects: ADME; DFT; Multi docking; Nirmatrelvir/Ritonavir; Synergetic drugs; Nirmatrelvir/Ritonavir; Multi docking; DFT; ADME; Synergetic drugs

Although the severity of the spread of corona virus has recently decreased. On this day, there is no available effective medication established to treat COVID-19. Combination drug therapy has been recently gained new momentum as an important platform to design and develop several anti-infective agen...