Physiologically Based Absorption Modeling to Design Extended-Release Clinical Products for an Ester Prodrug

• Published in: The AAPS journal Vol. 18; no. 6; pp. 1424 - 1438
• Main Authors: Ding, Xuan, Day, Jeffrey S., Sperry, David C.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2016
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Chemistry, Pharmaceutical - history; History, 20th Century; History, 21st Century; Nanotechnology; Pharmaceutical Preparations; Pharmacology/Toxicology; Pharmacy; Research Article; prodrug; product design; physiological model; extended release; oral absorption

ABSTRACT Absorption modeling has demonstrated its great value in modern drug product development due to its utility in understanding and predicting in vivo performance. In this case, we integrated physiologically based modeling in the development processes to effectively design extended-release (ER)...