Comparative proteomics uncovers vital molecular players of central nervous system leukemia among Mexican pediatric patients

• Published in: Journal of proteomics Vol. 318; p. 105458
• Main Authors: Ruiz-May, Eliel, Bojórquez-Velázquez, Esaú, Carrasco-Vargas, Humberto, Soto-Alvarez, Silverio, Rangel-Cova, Laura S., Vargas-Hernández, Marco Antonio, Elizalde-Contreras, José M., Torres De La Cruz, Víctor M., Vilchis-Ordoñez, Armando, Palomo-Colli, Miguel Ángel, Floriano, Tania Angeles, Ortega, Israel Parra, Pelayo-Camacho, Rosana, Huerta-Nuñez, Lidia F.E.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.06.2025
• Subjects: Acute lymphoblastic leukemia; Adolescent; Biomarkers, Tumor - cerebrospinal fluid; bone marrow; cadherins; cell adhesion; Central nervous system; Central Nervous System Neoplasms - cerebrospinal fluid; Central Nervous System Neoplasms - metabolism; cerebrospinal fluid; Child; Child, Preschool; Children; Female; glycosylation; homeostasis; Humans; Infant; Leukemic cells infiltration; lymphocytic leukemia; Male; Mexico; Neoplasm Proteins - cerebrospinal fluid; patients; Precursor Cell Lymphoblastic Leukemia-Lymphoma - cerebrospinal fluid; Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology; proteome; Proteome - metabolism; Proteomics; Proteomics - methods; quality of life; toxicity; Mexico; Leukemic cells infiltration; Children; Acute lymphoblastic leukemia; Central nervous system; Proteomics

Acute lymphoblastic leukemia (ALL) is the most common pediatric hematologic malignancy. The leukemic cells start in the bone marrow and spread to other vital organs and tissues, including the central nervous system (CNS). Hispanic males are the community with the highest incidence of ALL. Unfortunat...