Genetic diversity and proviral DNA load in different neural compartments of HIV-1 subtype C infection

• Published in: Journal of neurovirology Vol. 21; no. 4; pp. 399 - 414
• Main Authors: Mishra, Mamata, Varghese, Rebu K., Verma, Anjali, Das, Sutanuka, Aguiar, Renato Santana, Tanuri, Amilcar, Mahadevan, Anita, Shankar, Susarla K., Satishchandra, Parthasarathy, Ranga, Udaykumar
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2015
• Subjects: Adult; Amino Acid Sequence; Biomedical and Life Sciences; Biomedicine; Brain - virology; DNA, Viral - analysis; env Gene Products, Human Immunodeficiency Virus - genetics; Female; Genetic Variation; HIV Infections - virology; HIV-1 - genetics; Humans; Immunology; Infectious Diseases; Male; Middle Aged; Molecular Sequence Data; Neurology; Neurosciences; Phylogeny; Proviruses; Real-Time Polymerase Chain Reaction; Viral Load; Virology; HIV-1; HIV-associated dementia; Subtype C; Proviral load
• ISSN: 1355-0284; 1538-2443; 1538-2443
• DOI: 10.1007/s13365-015-0328-0

In India, the low prevalence of HIV-associated dementia (HAD) in the Human immunodeficiency virus type 1 (HIV-1) subtype C infection is quite paradoxical given the high-rate of macrophage infiltration into the brain. Whether the direct viral burden in individual brain compartments could be associate...