Concomitant [ 18 F]F-FAZA and [ 18 F]F-FDG Imaging of Gynecological Cancer Xenografts: Insight into Tumor Hypoxia

• Published in: In vivo (Athens) Vol. 38; no. 2; pp. 574 - 586
• Main Authors: Kepes, Zita, Hegedus, Eva, Sass, Tamas, Csikos, Csaba, Szabo, Judit P, Szugyiczki, Viktoria, Hajdu, István, Kertesz, Istvan, Opposits, Gabor, Imrek, Jozsef, Balkay, Laszlo, Kalman, Ferenc Krisztián, Trencsenyi, Gyorgy
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.03.2024
• Subjects: Animals; Cell Line, Tumor; Cobalt; Female; Fluorodeoxyglucose F18; Heterografts; Humans; Hypoxia - diagnostic imaging; Mice; Ovarian Neoplasms - diagnostic imaging; Positron-Emission Tomography - methods; Radiopharmaceuticals; Tumor Hypoxia; hypoxia; hypoxia-inducible factor-1α (HIF-1α); [18F]F-FAZA; [18F]F-FDG; Cervix xenotransplants; hexokinase enzyme-II; positron emission tomography (PET); preclinical; GLUT-1 transporter; ovarian xenotransplants

Herein we assessed the feasibility of imaging protocols using both hypoxia-specific [ F]F-FAZA and [ F]F-FDG in bypassing the limitations derived from the non-specific findings of [ F]F-FDG PET imaging of tumor-related hypoxia. CoCl -generated hypoxia was induced in multidrug resistant (Pgp+) or sen...