Evidence of a novel gene locus ARHGAP44 for longitudinal change in hemoglobin A1c levels among subjects without diabetes from the Long Life Family Study - Wang, Siyu; Lenzini, Petra; Thyagarajan, Bharat; Lee, Joseph H.; Vardarajan, Badri N.; Yashin, Anatoli; Miljkovic, Iva; Daw, E. Warwick; Lin, Shiow J.; Patti, Gary J.; Brent, Michael R.; Zmuda, Joseph M.; et al. (Physiological genomics, 2025)
Keywords: Aged; Chromosome 17; Cognitive ability; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - genetics; Female; Gene loci; Genetic Linkage; Genetic Loci - genetics; Genome-Wide Association Study; Genomic analysis; Glycated Hemoglobin - genetics; Glycated Hemoglobin - metabolism; GTPase-Activating Proteins - genetics; Hemoglobin; Humans; Insulin resistance; Linkage analysis; Longevity - genetics; Longitudinal Studies; Male; Middle Aged; Nucleotide sequence; Polymorphism, Single Nucleotide - genetics; Sequence analysis; ARHGAP44; glycated hemoglobin A1c; linkage-guided sequence and multi-omics data analysis; family members without diabetes