Scleraxis and fibrosis in the pressure-overloaded heart

• Published in: European heart journal Vol. 43; no. 45; pp. 4739 - 4750
• Main Authors: Nagalingam, Raghu S, Chattopadhyaya, Sikta, Al-Hattab, Danah S, Cheung, David Y C, Schwartz, Leah Y, Jana, Sayantan, Aroutiounova, Nina, Ledingham, D Allison, Moffatt, Teri L, Landry, Natalie M, Bagchi, Rushita A, Dixon, Ian M C, Wigle, Jeffrey T, Oudit, Gavin Y, Kassiri, Zamaneh, Jassal, Davinder S, Czubryt, Michael P
• Format: Journal Article
• Language: English
• Published: England 01.12.2022
• Subjects: Animals; Cardiomegaly - metabolism; Fibroblasts - metabolism; Fibrosis; Heart Failure - pathology; Mice; Mice, Inbred C57BL; Myocardium - pathology; Myofibroblasts - metabolism; Ventricular Remodeling; Heart failure; Cardiac fibrosis; Pressure overload; Transcription; Fibroblast; Myofibroblast

In response to pro-fibrotic signals, scleraxis regulates cardiac fibroblast activation in vitro via transcriptional control of key fibrosis genes such as collagen and fibronectin; however, its role in vivo is unknown. The present study assessed the impact of scleraxis loss on fibroblast activation,...