Effect of Huannao Yicong Prescription (还脑益聪方) extract on β-Amyloid precursor protein metabolic signal transduction-related protein in brain tissue of dementia model transgenic mouse

• Published in: Chinese journal of integrative medicine Vol. 18; no. 9; pp. 683 - 689
• Main Authors: Li, Hao, Liu, Ming-fang, Liu, Jian-gang, Liu, Long-tao, Guan, Jie, Cai, Lin-lin, Hu, Jia, Wei, Yun
• Format: Journal Article
• Language: English
• Published: Heidelberg Chinese Association of Traditional and Western Medicine 01.09.2012
• Subjects: Amyloid beta-Protein Precursor - metabolism; Animals; Brain - drug effects; Brain - enzymology; Brain - metabolism; Brain - pathology; Chromatography, High Pressure Liquid; Dementia - metabolism; Dementia - pathology; Disease Models, Animal; Drugs, Chinese Herbal - pharmacology; Female; Glycogen Synthase Kinase 3 - metabolism; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - pathology; Male; Medicine; Medicine & Public Health; Memory - drug effects; Mice; Mice, Inbred C57BL; Mice, Transgenic; Original Article; Plant Extracts - pharmacology; Protein Kinase C - metabolism; Receptor, trkA - metabolism; Signal Transduction - drug effects; amyloid precursor protein transgenic mice; Huannao Yicong Prescription extract; glycogen synthase-3; Alzheimer’s disease; protein kinase C; tryrosine amyloid protein kinase

Objective To observe the effect of Huannao Yicong Prescription (还脑益聪方, HNYC, a Chinese medical compound) extract on β-amyloid precursor protein (APP) metabolic signal transductionrelated protein kinase C (PKC), tyrosine amyloid protein kinase (TrKA), and glycogen synthase kinase-3 (GSK-3) in brain t...