Expression of extracellular matrix and adhesion proteins in pelvic organ prolapse

• Published in: Cellular and Molecular Biology Vol. 64; no. 5; pp. 142 - 148
• Main Authors: Cecati, Monica, Corradetti, Alessandra, Sartini, Davide, Pozzi, Valentina, Giannubilo, Stefano R, Saccucci, Franca, Ciavattini, Andrea, Emanuelli, Monica
• Format: Journal Article
• Language: English
• Published: France 30.04.2018
• Subjects: Actins - genetics; Actins - metabolism; Adult; Case-Control Studies; Extracellular Matrix - metabolism; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; Female; Gene Expression Profiling; Gene Expression Regulation; Humans; Hysterectomy; Integrin beta3 - genetics; Integrin beta3 - metabolism; Middle Aged; Pelvic Organ Prolapse - genetics; Pelvic Organ Prolapse - metabolism; Pelvic Organ Prolapse - pathology; Pelvic Organ Prolapse - surgery; Vagina - surgery; Adhesion molecules; Imbalanced expression level; Real-Time PCR; Pelvic organ prolapse

Pelvic organ prolapse (POP) is a common disorder in women. It is characterized by the descent of the vaginal wall with consequent drop of pelvic organs. Pregnancy, labour and childbirth seem to be important events leading to the development of POP, since they are associated with prolonged stretch an...