Sensitive detection of SARS-CoV-2 spike protein based on electrochemical impedance spectroscopy of Fe3O4@SiO2–Au/GCE biosensor

Highly contagious COVID-19 disease is caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which poses a serious threat to global public health. Therefore, the development of a fast and reliable method for the detection of SARS-CoV-2 is an urgent research need. The Fe3O4@S...

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Published inAdvanced Sensor and Energy Materials Vol. 2; no. 3; p. 100067
Main Authors You, Xun-Hai, Liu, Yao, Li, Yan-Yan, Zhao, Bing, Yang, Yong, Weerasooriya, Rohan, Chen, Xing
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.09.2023
Elsevier
Subjects
Electrochemical biosensor
Electrochemical impedance spectroscopy
Fe3O4@SiO2–Au nanocomposites
SARS-CoV-2 spike protein
SARS-CoV-2 spike protein
Electrochemical biosensor
Fe3O4@SiO2–Au nanocomposites
Electrochemical impedance spectroscopy
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Abstract Highly contagious COVID-19 disease is caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which poses a serious threat to global public health. Therefore, the development of a fast and reliable method for the detection of SARS-CoV-2 is an urgent research need. The Fe3O4@SiO2–Au is enriched with a variety of functional groups, which can be used to fabricate a sensitive electrochemical biosensor by biofunctionalization with angiotensin-converting enzyme 2 (ACE2). Accordingly, we developed a novel electrochemical sensor by chemically modifying a glassy carbon electrode (GCE) with Fe3O4@SiO2–Au nanocomposites (hereafter Fe3O4@SiO2–Au/GCE) for the rapid detection of S-protein spiked SARS-CoV-2 by electrochemical impedance spectroscopy (EIS). The new electrochemical sensor has a low limit detection (viz., 4.78 pg/mL) and a wide linear dynamic range (viz., 0.1 ng/mL to 10 μg/mL) for detecting the EIS response signal of S-protein. The robust Fe3O4@SiO2–Au/GCE biosensor has high selectivity, stability, and reproducibility for the detection of S-protein with good recovery of saliva samples. Electrochemical detection of SARS-CoV-2 spike protein based on Fe3O4@SiO2–Au/GCE biosensor. [Display omitted]
AbstractList Highly contagious COVID-19 disease is caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which poses a serious threat to global public health. Therefore, the development of a fast and reliable method for the detection of SARS-CoV-2 is an urgent research need. The Fe3O4@SiO2–Au is enriched with a variety of functional groups, which can be used to fabricate a sensitive electrochemical biosensor by biofunctionalization with angiotensin-converting enzyme 2 (ACE2). Accordingly, we developed a novel electrochemical sensor by chemically modifying a glassy carbon electrode (GCE) with Fe3O4@SiO2–Au nanocomposites (hereafter Fe3O4@SiO2–Au/GCE) for the rapid detection of S-protein spiked SARS-CoV-2 by electrochemical impedance spectroscopy (EIS). The new electrochemical sensor has a low limit detection (viz., 4.78 pg/mL) and a wide linear dynamic range (viz., 0.1 ng/mL to 10 μg/mL) for detecting the EIS response signal of S-protein. The robust Fe3O4@SiO2–Au/GCE biosensor has high selectivity, stability, and reproducibility for the detection of S-protein with good recovery of saliva samples. Electrochemical detection of SARS-CoV-2 spike protein based on Fe3O4@SiO2–Au/GCE biosensor. [Display omitted]
Highly contagious COVID-19 disease is caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which poses a serious threat to global public health. Therefore, the development of a fast and reliable method for the detection of SARS-CoV-2 is an urgent research need. The Fe3O4@SiO2–Au is enriched with a variety of functional groups, which can be used to fabricate a sensitive electrochemical biosensor by biofunctionalization with angiotensin-converting enzyme 2 (ACE2). Accordingly, we developed a novel electrochemical sensor by chemically modifying a glassy carbon electrode (GCE) with Fe3O4@SiO2–Au nanocomposites (hereafter Fe3O4@SiO2–Au/GCE) for the rapid detection of S-protein spiked SARS-CoV-2 by electrochemical impedance spectroscopy (EIS). The new electrochemical sensor has a low limit detection (viz., 4.78 pg/mL) and a wide linear dynamic range (viz., 0.1 ng/mL to 10 μg/mL) for detecting the EIS response signal of S-protein. The robust Fe3O4@SiO2–Au/GCE biosensor has high selectivity, stability, and reproducibility for the detection of S-protein with good recovery of saliva samples.
ArticleNumber 100067
Author Liu, Yao
You, Xun-Hai
Chen, Xing
Weerasooriya, Rohan
Zhao, Bing
Li, Yan-Yan
Yang, Yong
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  givenname: Xing
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  email: xingchen@hfut.edu.cn
  organization: Key Lab of Aerospace Structural Parts Forming Technology and Equipment of Anhui Province, Institute of Industry and Equipment Technology, Hefei University of Technology, Hefei 230009, PR China
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Issue 3
Keywords SARS-CoV-2 spike protein
Electrochemical biosensor
Fe3O4@SiO2–Au nanocomposites
Electrochemical impedance spectroscopy
Language English
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Snippet Highly contagious COVID-19 disease is caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which poses a serious threat to global...
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SubjectTerms Electrochemical biosensor
Electrochemical impedance spectroscopy
Fe3O4@SiO2–Au nanocomposites
SARS-CoV-2 spike protein
Title Sensitive detection of SARS-CoV-2 spike protein based on electrochemical impedance spectroscopy of Fe3O4@SiO2–Au/GCE biosensor
URI https://dx.doi.org/10.1016/j.asems.2023.100067
https://doaj.org/article/41c545ca7e0d485d8987e8c09bf6f50c
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