TNF-α provokes electrical abnormalities in rat atrial myocardium via a NO-dependent mechanism

• Published in: Pflügers Archiv Vol. 465; no. 12; pp. 1741 - 1752
• Main Authors: Abramochkin, Denis V., Kuzmin, Vladislav S., Mitrochin, Vadim M., Kalugin, Leonid, Dvorzhak, Anton, Makarenko, Ekaterina Y., Schubert, Rudolf, Kamkin, Andre
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2013
• Subjects: Action Potentials - drug effects; Animals; Arrhythmias, Cardiac - chemically induced; Atrial Function - drug effects; Atrial Function - physiology; Biomedical and Life Sciences; Biomedicine; Cell Biology; Electrophysiology; Gadolinium - pharmacology; Heart Atria - metabolism; Human Physiology; Ion Channels; Male; Membrane Potentials - drug effects; Molecular Medicine; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - physiology; Neurosciences; Nitric Oxide - physiology; Physical Stimulation; Rats; Rats, Wistar; Receptors; Receptors and Transporters; S-Nitroso-N-Acetylpenicillamine - pharmacology; Tumor Necrosis Factor-alpha - pharmacology; Heart; Stretch; Atrium; NO; Action potential; Cytokine

Stretch-induced depolarizations of cardiomyocytes, which are related to activity of mechano-gated cation channels (MGCs), can lead to serious arrhythmias. However, signaling pathways leading to activation of mechano-gated channels by stretch remain almost unexplored. Using standard sharp microelectr...