Subcellular chemical imaging of structurally similar acridine drugs by near-field laser desorption/laser postionization mass spectrometry

• Published in: Nano research Vol. 13; no. 3; pp. 745 - 751
• Main Authors: Cheng, Xiaoling, Yin, Zhibin, Rong, Liu, Hang, Wei
• Format: Journal Article
• Language: English
• Published: Beijing Tsinghua University Press 01.03.2020
• Subjects: Acridine; Atomic/Molecular Structure and Spectra; Biomedicine; Biotechnology; Chemistry and Materials Science; Condensed Matter Physics; Confocal microscopy; Desorption; Drug development; Drug interaction; Drugs; Imaging; Laser applications; Lasers; Lysosomes; Mass spectrometry; Mass spectroscopy; Materials Science; Metabolites; Nanotechnology; Near fields; Phenotypes; Research Article; Scientific imaging; Spatial distribution; Spectroscopy; Temporal distribution; acridine drugs; single cell imaging; mass spectrometry; near-field; laser postionization

Insights into the pharmacologic effect on cellular processes and the potential toxicological effects are vital to new drug development and evaluation, yet research on these subjects remains a great challenge due to the lack of information regarding the spatiotemporal distribution of drugs and metabo...