Aldehyde dehydrogenase 2 protects against abdominal aortic aneurysm formation by reducing reactive oxygen species, vascular inflammation, and apoptosis of vascular smooth muscle cells

• Published in: The FASEB journal Vol. 34; no. 7; p. 9498
• Main Authors: Tsai, Shih-Hung, Hsu, Lung-An, Tsai, Hsiao-Ya, Yeh, Yung-Hsin, Lu, Cheng-Yo, Chen, Po-Chuan, Wang, Jen-Chun, Chiu, Yi-Lin, Lin, Chih-Yuan, Hsu, Yu-Juei
• Format: Journal Article
• Language: English
• Published: United States 01.07.2020
• Subjects: Aldehyde Dehydrogenase, Mitochondrial - physiology; Animals; Aortic Aneurysm, Abdominal - immunology; Aortic Aneurysm, Abdominal - metabolism; Aortic Aneurysm, Abdominal - pathology; Aortic Aneurysm, Abdominal - prevention & control; Apoptosis; Disease Models, Animal; Female; Inflammation - immunology; Inflammation - metabolism; Inflammation - pathology; Inflammation - prevention & control; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria - immunology; Mitochondria - metabolism; Mitochondria - pathology; Muscle, Smooth, Vascular - immunology; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Oxidative Stress; Protective Agents; Reactive Oxygen Species - metabolism; aldehyde dehydrogenase 2; 4-hydroxy-2-nonenal; angiotensin II; abdominal aortic aneurysm; reactive oxygen species

Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is an enzyme that detoxifies aldehydes by converting them to carboxylic acids. ALDH2 deficiency is known to increase oxidative stress. Increased oxidative stress plays a pivotal role in abdominal aortic aneurysm (AAA) pathogenesis. Reactive oxygen speci...