A Pilot Study Comparing HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas by Whole Exome Sequencing

• Published in: ISRN oncology Vol. 2012; no. 2012; pp. 1 - 9
• Main Authors: Basmaji, John, Dhaliwal, Sandeep, Xu, Wei, Yoo, John, Chan-Seng-Yue, Michelle, Nichols, Anthony C., Szeto, Christopher C. T., Dowthwaite, Samuel A., Todorovic, Biljana, Starmans, Maud H. W., Lambin, Philippe, Palma, David A., Fung, Kevin, Franklin, Jason H., Wehrli, Bret, Kwan, Keith, Koropatnick, James, Mymryk, Joe S., Boutros, Paul C., Barrett, John W.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Puplishing Corporation 2012; International Scholarly Research Network; Hindawi Limited
• Subjects: biomarkers; Blood; Cancer; DNA; Exons; Genomes; Head & neck cancer; Head and neck; Head and neck cancer; Health sciences; Human papillomavirus; Infection; Medical research; mucin; Mutation; Oncology; Patients; squamous cell carcinoma; Surgery; Tongue; Tonsil; Tumors; Zinc finger proteins

Background. Next-generation sequencing of cancers has identified important therapeutic targets and biomarkers. The goal of this pilot study was to compare the genetic changes in a human papillomavirus- (HPV-)positive and an HPV-negative head and neck tumor. Methods. DNA was extracted from the blood...