Specific epigenetic age acceleration patterns among four molecular subtypes of gastric cancer and their prognostic value

• Published in: Epigenomics Vol. 13; no. 10; pp. 767 - 778
• Main Authors: Zhou, Yu-Jie, Lu, Xiao-Fan, Meng, Jia-Lin, Wang, Qi-Wen, Chen, Jin-Nan, Zhang, Qing-Wei, Zheng, Kenneth I, Rocha, Claudia S, Martins, Carla B, Yan, Fang-Rong, Li, Xiao-Bo
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.05.2021
• Subjects: age acceleration; Aging - genetics; DNA Methylation; Epigenesis, Genetic; Epstein-Barr Virus Infections - genetics; Female; gastric cancer; Genomic Instability; Humans; Male; Middle Aged; molecular subtype; Prognosis; Stomach Neoplasms - classification; Stomach Neoplasms - genetics; survival; gastric cancer; age acceleration; molecular subtype; survival

To determine the association of the methylation age (Horvath epigenetic clock) of gastric cancer (GC) tissues with molecular subtypes and patient survival. Multivariate regression models were used to determine the association of methylation age acceleration (AA) with the clinical and molecular chara...