Recent advances in organocatalytic asymmetric oxa-Michael addition triggered cascade reactions

The oxa-Michael cascade reaction, as an important part of the Michael reaction, has also been significantly developed over the recent decade. This is because the problem of the reactivity and selectivity of the addition reactions of oxygen nucleophiles to conjugated systems has been solved by differ...

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Published inOrganic chemistry frontiers an international journal of organic chemistry Vol. 7; no. 20; pp. 3266 - 3283
Main Authors Wang, Yu, Da-Ming, Du
Format Journal Article
LanguageEnglish
Published London Royal Society of Chemistry 21.10.2020
Subjects
Asymmetry
Cascade chemical reactions
Chemical synthesis
Heterocyclic compounds
Michael reaction
Nucleophiles
Organic chemistry
Selectivity
Stereoselectivity
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Summary:The oxa-Michael cascade reaction, as an important part of the Michael reaction, has also been significantly developed over the recent decade. This is because the problem of the reactivity and selectivity of the addition reactions of oxygen nucleophiles to conjugated systems has been solved by different organocatalysts and reaction conditions. Therefore, using various efficient strategies, many novel and potentially bioactive chiral compounds with excellent yields and stereoselectivities have been synthesized. In this review, we summarize the recent advances in organocatalytic asymmetric oxa-Michael addition triggered cascade reactions for the stereoselective synthesis of heterocyclic compounds.
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ISSN:2052-4110
2052-4110
DOI:10.1039/d0qo00631a