Synthesis of size-controllable Fe3O4 magnetic submicroparticles and its biocompatible evaluation in vitro
Large scaled uniform and size-controllable magnetic submicroparticles (MSPs) were synthesized via solvothermal method with ferric chloride as iron source and sodium acetate as trapping agent. The influence of Fe 3+ and NaAc contents on the size distribution of MSPs was investigated. The structural a...
Saved in:
| Published in | Journal of Central South University Vol. 23; no. 11; pp. 2784 - 2791 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Changsha
Central South University
01.11.2016
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Large scaled uniform and size-controllable magnetic submicroparticles (MSPs) were synthesized via solvothermal method with ferric chloride as iron source and sodium acetate as trapping agent. The influence of Fe
3+
and NaAc contents on the size distribution of MSPs was investigated. The structural and morphological properties of the synthesized particles were studied by scanning electron microscopy (SEM), X-ray power diffraction (XRD) and vibrating sample magnetometer (VSM). The well-dispersed MSPs with size of 100-1000 nm were obtained by simply adjusting the contents of Fe
3+
and NaAc. In addition, the hemolysis and cytotoxicity of Fe
3
O
4
MSPs, and their ability to case arrest in cell life-cycles were studied. The results indicate that larger size could lead to lower hemolysis. From MTT(3-(4,5-dimethylthuazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the interactions between MSPs and adhesive mouse fibroblast cell line(L929) were probed. Larger size of Fe
3
O
4
MSPs demonstrates lower cell viability following an exposure to the cells. |
|---|---|
| AbstractList | Large scaled uniform and size-controllable magnetic submicroparticles (MSPs) were synthesized via solvothermal method with ferric chloride as iron source and sodium acetate as trapping agent. The influence of Fe
3+
and NaAc contents on the size distribution of MSPs was investigated. The structural and morphological properties of the synthesized particles were studied by scanning electron microscopy (SEM), X-ray power diffraction (XRD) and vibrating sample magnetometer (VSM). The well-dispersed MSPs with size of 100-1000 nm were obtained by simply adjusting the contents of Fe
3+
and NaAc. In addition, the hemolysis and cytotoxicity of Fe
3
O
4
MSPs, and their ability to case arrest in cell life-cycles were studied. The results indicate that larger size could lead to lower hemolysis. From MTT(3-(4,5-dimethylthuazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the interactions between MSPs and adhesive mouse fibroblast cell line(L929) were probed. Larger size of Fe
3
O
4
MSPs demonstrates lower cell viability following an exposure to the cells. Large scaled uniform and size-controllable magnetic submicroparticles (MSPs) were synthesized via solvothermal method with ferric chloride as iron source and sodium acetate as trapping agent. The influence of Fe3+ and NaAc contents on the size distribution of MSPs was investigated. The structural and morphological properties of the synthesized particles were studied by scanning electron microscopy (SEM), X-ray power diffraction (XRD) and vibrating sample magnetometer (VSM). The well-dispersed MSPs with size of 100-1000 nm were obtained by simply adjusting the contents of Fe3+ and NaAc. In addition, the hemolysis and cytotoxicity of Fe3O4 MSPs, and their ability to case arrest in cell life-cycles were studied. The results indicate that larger size could lead to lower hemolysis. From MTT(3-(4,5-dimethylthuazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the interactions between MSPs and adhesive mouse fibroblast cell line(L929) were probed. Larger size of Fe3O4 MSPs demonstrates lower cell viability following an exposure to the cells. |
| Author | Yuan, Xiu-hong Bai, Zhi-ming Ning, Wen-bo Tian, Qing-hua Wang, Wei-jia |
| Author_xml | – sequence: 1 givenname: Qing-hua surname: Tian fullname: Tian, Qing-hua email: qinghua@csu.edu.cn organization: School of Metallurgy and Enviroment, Cental South University – sequence: 2 givenname: Wen-bo surname: Ning fullname: Ning, Wen-bo organization: School of Metallurgy and Enviroment, Cental South University – sequence: 3 givenname: Wei-jia surname: Wang fullname: Wang, Wei-jia organization: School of Metallurgy and Enviroment, Cental South University – sequence: 4 givenname: Xiu-hong surname: Yuan fullname: Yuan, Xiu-hong organization: School of Metallurgy and Enviroment, Cental South University – sequence: 5 givenname: Zhi-ming surname: Bai fullname: Bai, Zhi-ming organization: Haikou Municipal People’s Hospital |
| BookMark | eNp9kF9LXDEQxYMouFo_gG8Bn9Pm301yH4u4VRB8aPsccuNkjdxN1iQrrJ_erNuHUqhPMwPnN3PmnKHjlBMgdMnoV0ap_lYZ05oRyhQRQjIij9CCc67JwLk47j0dB8LNOJ6ii1rjRAXjSqhRLVD8uUvtCWqsOAdc4xsQn1MreZ7dNANegniQeO1WCVr0uG6ndfQlb1zp4wwVu_SIY6t4itnn9ca1uMfg1c3b3ueEY8KvsS_8gk6Cmytc_Knn6Pfy5tf1Lbl_-HF3_f2eeCFFI06boKUOEqgcFdDHwQUzCGqccSOoMBmqQEofONUhDFNwQUx6UGHw1Adw4hxdHfZuSn7ZQm32OW9L6ictM4YaLrgaukofVP2ZWgsE62P7MNyKi7Nl1O6jtYdobY_W7qO1spPsH3JT4tqV3acMPzC1a9MKyl-e_gu9A_O0j5U |
| CitedBy_id | crossref_primary_10_1016_j_micromeso_2020_110775 crossref_primary_10_1021_acsanm_2c03537 crossref_primary_10_4236_anp_2021_104008 crossref_primary_10_1016_j_ijpharm_2022_122064 crossref_primary_10_1039_D3TC02786D crossref_primary_10_1038_s41598_020_75669_3 crossref_primary_10_3390_nano9121791 |
| Cites_doi | 10.1016/j.jmmm.2006.07.037 10.1088/0022-3727/36/13/201 10.1109/20.951263 10.1016/j.ijpharm.2006.06.029 10.1289/ehp.7339 10.1021/ja016812s 10.1002/1521-4095(200107)13:14<1090::AID-ADMA1090>3.0.CO;2-H 10.1016/j.jmmm.2005.02.078 10.1039/a904518j 10.1126/science.282.5391.1111 10.2131/jts.33.105 10.1007/978-1-4757-6482-6 10.1093/toxsci/kfj140 10.1002/ange.200462551 10.1182/blood.V76.11.2327.2327 10.1016/j.toxlet.2009.03.014 10.1126/science.304.5678.1732 10.1021/ie200970j 10.1038/nnano.2008.111 10.1126/science.1114397 10.1006/jcis.1998.5993 10.1021/cg900920q 10.1016/j.ssc.2003.11.043 10.1016/0378-5173(96)04539-5 |
| ContentType | Journal Article |
| Copyright | Central South University Press and Springer-Verlag Berlin Heidelberg 2016 Copyright Springer Science & Business Media 2016 |
| Copyright_xml | – notice: Central South University Press and Springer-Verlag Berlin Heidelberg 2016 – notice: Copyright Springer Science & Business Media 2016 |
| DBID | AAYXX CITATION |
| DOI | 10.1007/s11771-016-3341-4 |
| DatabaseName | CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Engineering |
| EISSN | 2227-5223 |
| EndPage | 2791 |
| ExternalDocumentID | 10_1007_s11771_016_3341_4 |
| GroupedDBID | -03 -0C -EM -SC -S~ .VR 06D 0R~ 29~ 2B. 2C0 2J2 2JN 2JY 2KG 2KM 2LR 30V 4.4 406 408 40E 5VR 5VS 8UJ 92H 92I 92M 92R 93N 95- 95. 95~ 96X 9D9 9DC AABHQ AACDK AAHNG AAIAL AAJBT AAJKR AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAXDM AAYIU AAYQN AAYTO AAYZH ABAKF ABDZT ABECU ABFTV ABHQN ABJNI ABJOX ABKCH ABMQK ABNWP ABQBU ABSXP ABTEG ABTHY ABTKH ABTMW ABWNU ABXPI ACAOD ACBXY ACDTI ACGFS ACHSB ACHXU ACIWK ACKNC ACMDZ ACMLO ACOKC ACPIV ACSNA ACZOJ ADHIR ADINQ ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADZKW AEBTG AEFQL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFLOW AFQWF AFUIB AFZKB AGAYW AGDGC AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHBYD AHKAY AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJRNO ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AOCGG ARCEE ARMRJ AXYYD B-. BA0 BDATZ BGNMA CAJEC CCEZO CEKLB CHBEP CSCUP DDRTE DNIVK DPUIP EBLON EBS EIOEI EJD ESBYG FA0 FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 HF~ HG6 HMJXF HRMNR IKXTQ IWAJR IXD I~Z J-C JBSCW JUIAU JZLTJ KOV LLZTM M4Y MA- NPVJJ NQJWS NU0 O9J PF0 PT4 Q-- Q-2 R-C R89 ROL RPX RSV RT3 S16 S3B SAP SCL SCLPG SDH SEG SHX SISQX SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW STPWE SZN T8S TCJ TGT TSG TUC U1F U1G U2A U5C U5M UG4 UOJIU UTJUX UZXMN VC2 VFIZW W48 YLTOR Z7R Z7V Z7X Z7Y Z7Z Z81 Z83 Z85 Z88 ZMTXR ~A9 AAPKM AAYXX ABBRH ABDBE ABFSG ACSTC AEZWR AFDZB AFHIU AFOHR AHPBZ AHWEU AIXLP ATHPR AYFIA CITATION ABRTQ |
| ID | FETCH-LOGICAL-c343t-a78f747f4e0496e0d5af85308a8a9e6fb806e44cf207ff5bfaf3b756f5c0cfea3 |
| IEDL.DBID | U2A |
| ISSN | 2095-2899 |
| IngestDate | Fri Jul 25 11:16:06 EDT 2025 Thu Apr 24 23:07:50 EDT 2025 Tue Jul 01 00:29:18 EDT 2025 Fri Feb 21 02:34:54 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Keywords | magnetite submicroparticles biocompatibility hemolysis cytotoxicity |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c343t-a78f747f4e0496e0d5af85308a8a9e6fb806e44cf207ff5bfaf3b756f5c0cfea3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 |
| PQID | 1880823265 |
| PQPubID | 2044301 |
| PageCount | 8 |
| ParticipantIDs | proquest_journals_1880823265 crossref_citationtrail_10_1007_s11771_016_3341_4 crossref_primary_10_1007_s11771_016_3341_4 springer_journals_10_1007_s11771_016_3341_4 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2016-11-01 |
| PublicationDateYYYYMMDD | 2016-11-01 |
| PublicationDate_xml | – month: 11 year: 2016 text: 2016-11-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Changsha |
| PublicationPlace_xml | – name: Changsha – name: Heidelberg |
| PublicationSubtitle | Science & Technology of Mining and Metallurgy |
| PublicationTitle | Journal of Central South University |
| PublicationTitleAbbrev | J. Cent. South Univ |
| PublicationYear | 2016 |
| Publisher | Central South University Springer Nature B.V |
| Publisher_xml | – name: Central South University – name: Springer Nature B.V |
| References | OberdörsterGOberdörsterEOberdörsterJNanotoxicology: An emerging discipline evolving from studies of ultrafine particles [J]Environmental Health Perspectives2005113782383910.1289/ehp.73390303.28009 KarlssonH LGustafssonJCronholmPMöllerLSize-dependent toxicity of metal oxide particles—A comparison between nano-and micrometer size [J]Toxicology Letters2009188211211810.1016/j.toxlet.2009.03.014 PolandC ADuffinRKinlochIMaynardAWallaceW ASeatonAStoneVBrownSMacneeWDonaldsonKCarbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study [J]Nature Nanotechnology20083742342810.1038/nnano.2008.111 LiY-tLiuJZhongY-jZhangJWangZ-yWangLAnY-lLinMGaoZ-qZhangDonghengBiocompatibility of Fe3O4@Au composite magnetic nanoparticles in vitro and in vivo [J]International Journal of Nanomedicine201162805281910.2147/IJN.S24596 TingFPanD-kZhangHuiStudy on formation mechanism by monitoring the morphology and structure evolution of nearly monodispersed Fe3O4 submicroparticles with controlled particle sizes [J]Industrial & Engineering Chemistry Research201150159009901810.1021/ie200970j NelAXiaTMädlerLLiNToxic potential of materials at the nanolevel [J]Science2006311576162262710.1126/science.1114397 LianS-yWangE-bKangZ-hBaiY-pGaoLJiangMHuC-wXuLinSynthesis of magnetite nanorods and porous hematite nanorods [J]Solid State Commun200412948549010.1016/j.ssc.2003.11.043 XuJYangH-bFuW-yDuKSuiY-mChenJ-jZengYLiM-hZouG-tianPreparation and magnetic properties of magnetite nanoparticles by sol–gel method [J]Journal of Magnetism and Magnetic Materials2007309230731110.1016/j.jmmm.2006.07.037 CarusoFSpasovaMSalgueiriño-MaceiraVLizmarzánL MMultilayer assemblies of silica-encapsulated gold nanoparticles on decomposable colloid templates [J]Advanced Materials200113141090109410.1002/1521-4095(200107)13:14<1090::AID-ADMA1090>3.0.CO;2-H HyeonTLeeS SParkJChungYNaH BSynthesis of highly crystalline and monodisperse maghemite nanocrystallites without a size-selection process [J]Journal of the American Chemical Society200112351127981280110.1021/ja016812s PankhurstQ AConnollyJJonesS KDobsonJApplications of magnetic nanoparticles in biomedicine [J]Journal of Physics D: Applied Physics20033613R16710.1088/0022-3727/36/13/201 WarheitD BWebbT RSayesC MColvinV LReedL KPulmonary instillation studies with nanoscale TiO2 rods and dots in rats: Toxicity is not dependent upon particle size and surface area [J]Toxicological Sciences200691122723610.1093/toxsci/kfj140 KimD HLeeS HKimK NShimI BLeeY KCytotoxicity of ferrite particles by MTT and agar diffusion methods for hyperthermic application [J]Journal of Magnetism and Magnetic Materials20052931287292210121810.1016/j.jmmm.2005.02.078 CarusoFCarusoR AMöhwaldHNanoengineering of inorganic and hybrid hollow spheres by colloidal templating [J]Science199828253911111111410.1126/science.282.5391.1111 ZhangW-yShenYLiNanEvaluation of biocompatibility of fiber-reinforced dental composites [J]Medical Journal of Chinese People’s Liberation Army200429345347 HäfeliUSchüttWTellerJZborowskiMScientific and clinical applications of magnetic drug carriers [M]199710.1007/978-1-4757-6482-6 TakagiAHiroseANishimuraTFukumoriNOgataAOhashiNKitajimaSKannoJInduction of mesothelioma in p53+/-mouse by intraperitoneal application of multi-wall carbon nanotube [J]The Journal of Toxicological Sciences200833110511610.2131/jts.33.105 SunJGuGQianYInfluence of different contact ways and extracting conditions on the hemolytic effect of biomaterials [J]Journal of Biomedical Engineering2003201810 PietersRLoonenA HHuismansD RBroekemaG JDirvenM WHeyenbrokM WHahlenKVeermanA JIn vitro drug sensitivity of cells from children with leukemia using the MTT assay with improved culture conditions [J]Blood1990761123272336 WuK TKuoP CYaoY DMagnetic and optical properties of Fe3O4 nanoparticle ferrofluids prepared by coprecipitation technique [J]IEEE Transactions on Magnetics20013742651265310.1109/20.951263 RaoCNRKulkarniG UThomasP JEdwardsP PMetal nanoparticles and their assemblies [J]Chemical Society Reviews2000291273510.1039/a904518j ZaitsevV SFilimonovD SPresnyakovI AGambinoR JChuBPhysical and chemical properties of magnetite and magnetitepolymer nanoparticles and their colloidal dispersions [J]Journal of Colloid and Interface Science1999212495710.1006/jcis.1998.5993 YangJParkS BYoonH GHuhY MHaamSPreparation of poly caprolactone nanoparticles containing magnetite for magnetic drug carrier [J]International Journal of Pharmaceutics2006324218519010.1016/j.ijpharm.2006.06.029 GaoG-hLiuX-hShiR-rZhouK-cShiY-gMaR-zhiShape-controlled synthesis and magnetic properties of monodisperse Fe3O4 nanocubes [J]Crystal Growth & Design20101072888289410.1021/cg900920q ServiceR FNanotechnology grows up [J]Science200430456781732173410.1126/science.304.5678.1732 MüllerR HMaaenSWeyhersHSpechtbFLucksbJ SCytotoxicity of magnetite-loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles [J]International Journal of Pharmaceutics19961381859410.1016/0378-5173(96)04539-5 DengHLiX-lPengQWangXChenJ-pLiY-dongMonodisperse magnetic single-crystal ferrite microspheres [J]Angewandte Chemie2005117182842284510.1002/ange.200462551 NelAXiaTMädlerLToxic potential of materials at the nanolevel [J]Science2006311576162262710.1126/science.1114397 R H Müller (3341_CR18) 1996; 138 F Ting (3341_CR22) 2011; 50 F Caruso (3341_CR9) 1998; 282 H Deng (3341_CR21) 2005; 117 W-y Zhang (3341_CR24) 2004; 29 G-h Gao (3341_CR7) 2010; 10 A Takagi (3341_CR15) 2008; 33 A Nel (3341_CR19) 2006; 311 F Caruso (3341_CR10) 2001; 13 C A Poland (3341_CR14) 2008; 3 V S Zaitsev (3341_CR3) 1999; 212 J Sun (3341_CR23) 2003; 20 T Hyeon (3341_CR8) 2001; 123 C Rao (3341_CR4) 2000; 29 D B Warheit (3341_CR20) 2006; 91 A Nel (3341_CR11) 2006; 311 K T Wu (3341_CR5) 2001; 37 S-y Lian (3341_CR2) 2004; 129 Q A Pankhurst (3341_CR17) 2003; 36 G Oberdörster (3341_CR13) 2005; 113 D H Kim (3341_CR27) 2005; 293 J Xu (3341_CR6) 2007; 309 R F Service (3341_CR12) 2004; 304 U Häfeli (3341_CR1) 1997 J Yang (3341_CR16) 2006; 324 H L Karlsson (3341_CR28) 2009; 188 R Pieters (3341_CR25) 1990; 76 Y-t Li (3341_CR26) 2011; 6 |
| References_xml | – reference: DengHLiX-lPengQWangXChenJ-pLiY-dongMonodisperse magnetic single-crystal ferrite microspheres [J]Angewandte Chemie2005117182842284510.1002/ange.200462551 – reference: PietersRLoonenA HHuismansD RBroekemaG JDirvenM WHeyenbrokM WHahlenKVeermanA JIn vitro drug sensitivity of cells from children with leukemia using the MTT assay with improved culture conditions [J]Blood1990761123272336 – reference: TakagiAHiroseANishimuraTFukumoriNOgataAOhashiNKitajimaSKannoJInduction of mesothelioma in p53+/-mouse by intraperitoneal application of multi-wall carbon nanotube [J]The Journal of Toxicological Sciences200833110511610.2131/jts.33.105 – reference: LianS-yWangE-bKangZ-hBaiY-pGaoLJiangMHuC-wXuLinSynthesis of magnetite nanorods and porous hematite nanorods [J]Solid State Commun200412948549010.1016/j.ssc.2003.11.043 – reference: PolandC ADuffinRKinlochIMaynardAWallaceW ASeatonAStoneVBrownSMacneeWDonaldsonKCarbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study [J]Nature Nanotechnology20083742342810.1038/nnano.2008.111 – reference: TingFPanD-kZhangHuiStudy on formation mechanism by monitoring the morphology and structure evolution of nearly monodispersed Fe3O4 submicroparticles with controlled particle sizes [J]Industrial & Engineering Chemistry Research201150159009901810.1021/ie200970j – reference: MüllerR HMaaenSWeyhersHSpechtbFLucksbJ SCytotoxicity of magnetite-loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles [J]International Journal of Pharmaceutics19961381859410.1016/0378-5173(96)04539-5 – reference: HäfeliUSchüttWTellerJZborowskiMScientific and clinical applications of magnetic drug carriers [M]199710.1007/978-1-4757-6482-6 – reference: CarusoFSpasovaMSalgueiriño-MaceiraVLizmarzánL MMultilayer assemblies of silica-encapsulated gold nanoparticles on decomposable colloid templates [J]Advanced Materials200113141090109410.1002/1521-4095(200107)13:14<1090::AID-ADMA1090>3.0.CO;2-H – reference: KimD HLeeS HKimK NShimI BLeeY KCytotoxicity of ferrite particles by MTT and agar diffusion methods for hyperthermic application [J]Journal of Magnetism and Magnetic Materials20052931287292210121810.1016/j.jmmm.2005.02.078 – reference: SunJGuGQianYInfluence of different contact ways and extracting conditions on the hemolytic effect of biomaterials [J]Journal of Biomedical Engineering2003201810 – reference: ZhangW-yShenYLiNanEvaluation of biocompatibility of fiber-reinforced dental composites [J]Medical Journal of Chinese People’s Liberation Army200429345347 – reference: XuJYangH-bFuW-yDuKSuiY-mChenJ-jZengYLiM-hZouG-tianPreparation and magnetic properties of magnetite nanoparticles by sol–gel method [J]Journal of Magnetism and Magnetic Materials2007309230731110.1016/j.jmmm.2006.07.037 – reference: NelAXiaTMädlerLToxic potential of materials at the nanolevel [J]Science2006311576162262710.1126/science.1114397 – reference: NelAXiaTMädlerLLiNToxic potential of materials at the nanolevel [J]Science2006311576162262710.1126/science.1114397 – reference: YangJParkS BYoonH GHuhY MHaamSPreparation of poly caprolactone nanoparticles containing magnetite for magnetic drug carrier [J]International Journal of Pharmaceutics2006324218519010.1016/j.ijpharm.2006.06.029 – reference: PankhurstQ AConnollyJJonesS KDobsonJApplications of magnetic nanoparticles in biomedicine [J]Journal of Physics D: Applied Physics20033613R16710.1088/0022-3727/36/13/201 – reference: LiY-tLiuJZhongY-jZhangJWangZ-yWangLAnY-lLinMGaoZ-qZhangDonghengBiocompatibility of Fe3O4@Au composite magnetic nanoparticles in vitro and in vivo [J]International Journal of Nanomedicine201162805281910.2147/IJN.S24596 – reference: OberdörsterGOberdörsterEOberdörsterJNanotoxicology: An emerging discipline evolving from studies of ultrafine particles [J]Environmental Health Perspectives2005113782383910.1289/ehp.73390303.28009 – reference: ZaitsevV SFilimonovD SPresnyakovI AGambinoR JChuBPhysical and chemical properties of magnetite and magnetitepolymer nanoparticles and their colloidal dispersions [J]Journal of Colloid and Interface Science1999212495710.1006/jcis.1998.5993 – reference: WarheitD BWebbT RSayesC MColvinV LReedL KPulmonary instillation studies with nanoscale TiO2 rods and dots in rats: Toxicity is not dependent upon particle size and surface area [J]Toxicological Sciences200691122723610.1093/toxsci/kfj140 – reference: KarlssonH LGustafssonJCronholmPMöllerLSize-dependent toxicity of metal oxide particles—A comparison between nano-and micrometer size [J]Toxicology Letters2009188211211810.1016/j.toxlet.2009.03.014 – reference: RaoCNRKulkarniG UThomasP JEdwardsP PMetal nanoparticles and their assemblies [J]Chemical Society Reviews2000291273510.1039/a904518j – reference: CarusoFCarusoR AMöhwaldHNanoengineering of inorganic and hybrid hollow spheres by colloidal templating [J]Science199828253911111111410.1126/science.282.5391.1111 – reference: GaoG-hLiuX-hShiR-rZhouK-cShiY-gMaR-zhiShape-controlled synthesis and magnetic properties of monodisperse Fe3O4 nanocubes [J]Crystal Growth & Design20101072888289410.1021/cg900920q – reference: WuK TKuoP CYaoY DMagnetic and optical properties of Fe3O4 nanoparticle ferrofluids prepared by coprecipitation technique [J]IEEE Transactions on Magnetics20013742651265310.1109/20.951263 – reference: HyeonTLeeS SParkJChungYNaH BSynthesis of highly crystalline and monodisperse maghemite nanocrystallites without a size-selection process [J]Journal of the American Chemical Society200112351127981280110.1021/ja016812s – reference: ServiceR FNanotechnology grows up [J]Science200430456781732173410.1126/science.304.5678.1732 – volume: 29 start-page: 345 year: 2004 ident: 3341_CR24 publication-title: Medical Journal of Chinese People’s Liberation Army – volume: 309 start-page: 307 issue: 2 year: 2007 ident: 3341_CR6 publication-title: Journal of Magnetism and Magnetic Materials doi: 10.1016/j.jmmm.2006.07.037 – volume: 36 start-page: R167 issue: 13 year: 2003 ident: 3341_CR17 publication-title: Journal of Physics D: Applied Physics doi: 10.1088/0022-3727/36/13/201 – volume: 37 start-page: 2651 issue: 4 year: 2001 ident: 3341_CR5 publication-title: IEEE Transactions on Magnetics doi: 10.1109/20.951263 – volume: 324 start-page: 185 issue: 2 year: 2006 ident: 3341_CR16 publication-title: International Journal of Pharmaceutics doi: 10.1016/j.ijpharm.2006.06.029 – volume: 113 start-page: 823 issue: 7 year: 2005 ident: 3341_CR13 publication-title: Environmental Health Perspectives doi: 10.1289/ehp.7339 – volume: 123 start-page: 12798 issue: 51 year: 2001 ident: 3341_CR8 publication-title: Journal of the American Chemical Society doi: 10.1021/ja016812s – volume: 13 start-page: 1090 issue: 14 year: 2001 ident: 3341_CR10 publication-title: Advanced Materials doi: 10.1002/1521-4095(200107)13:14<1090::AID-ADMA1090>3.0.CO;2-H – volume: 293 start-page: 287 issue: 1 year: 2005 ident: 3341_CR27 publication-title: Journal of Magnetism and Magnetic Materials doi: 10.1016/j.jmmm.2005.02.078 – volume: 29 start-page: 27 issue: 1 year: 2000 ident: 3341_CR4 publication-title: Chemical Society Reviews doi: 10.1039/a904518j – volume: 282 start-page: 1111 issue: 5391 year: 1998 ident: 3341_CR9 publication-title: Science doi: 10.1126/science.282.5391.1111 – volume: 33 start-page: 105 issue: 1 year: 2008 ident: 3341_CR15 publication-title: The Journal of Toxicological Sciences doi: 10.2131/jts.33.105 – volume: 20 start-page: 8 issue: 1 year: 2003 ident: 3341_CR23 publication-title: Journal of Biomedical Engineering – volume-title: Scientific and clinical applications of magnetic drug carriers [M] year: 1997 ident: 3341_CR1 doi: 10.1007/978-1-4757-6482-6 – volume: 91 start-page: 227 issue: 1 year: 2006 ident: 3341_CR20 publication-title: Toxicological Sciences doi: 10.1093/toxsci/kfj140 – volume: 117 start-page: 2842 issue: 18 year: 2005 ident: 3341_CR21 publication-title: Angewandte Chemie doi: 10.1002/ange.200462551 – volume: 76 start-page: 2327 issue: 11 year: 1990 ident: 3341_CR25 publication-title: Blood doi: 10.1182/blood.V76.11.2327.2327 – volume: 188 start-page: 112 issue: 2 year: 2009 ident: 3341_CR28 publication-title: Toxicology Letters doi: 10.1016/j.toxlet.2009.03.014 – volume: 304 start-page: 1732 issue: 5678 year: 2004 ident: 3341_CR12 publication-title: Science doi: 10.1126/science.304.5678.1732 – volume: 50 start-page: 9009 issue: 15 year: 2011 ident: 3341_CR22 publication-title: Industrial & Engineering Chemistry Research doi: 10.1021/ie200970j – volume: 3 start-page: 423 issue: 7 year: 2008 ident: 3341_CR14 publication-title: Nature Nanotechnology doi: 10.1038/nnano.2008.111 – volume: 311 start-page: 622 issue: 5761 year: 2006 ident: 3341_CR19 publication-title: Science doi: 10.1126/science.1114397 – volume: 212 start-page: 49 year: 1999 ident: 3341_CR3 publication-title: Journal of Colloid and Interface Science doi: 10.1006/jcis.1998.5993 – volume: 10 start-page: 2888 issue: 7 year: 2010 ident: 3341_CR7 publication-title: Crystal Growth & Design doi: 10.1021/cg900920q – volume: 129 start-page: 485 year: 2004 ident: 3341_CR2 publication-title: Solid State Commun doi: 10.1016/j.ssc.2003.11.043 – volume: 311 start-page: 622 issue: 5761 year: 2006 ident: 3341_CR11 publication-title: Science doi: 10.1126/science.1114397 – volume: 6 start-page: 2805 year: 2011 ident: 3341_CR26 publication-title: International Journal of Nanomedicine – volume: 138 start-page: 85 issue: 1 year: 1996 ident: 3341_CR18 publication-title: International Journal of Pharmaceutics doi: 10.1016/0378-5173(96)04539-5 |
| SSID | ssib031263696 ssib051367662 ssib026412149 ssib016993150 ssib024508231 ssj0001192107 ssib009883398 ssib016971650 |
| Score | 2.0784173 |
| Snippet | Large scaled uniform and size-controllable magnetic submicroparticles (MSPs) were synthesized via solvothermal method with ferric chloride as iron source and... |
| SourceID | proquest crossref springer |
| SourceType | Aggregation Database Enrichment Source Index Database Publisher |
| StartPage | 2784 |
| SubjectTerms | Biocompatibility Chemical and Environmental Engineering Controllability Engineering Ferric chloride Hemolysis In vitro methods and tests Iron oxides Magnetic properties Materials Metallic Materials Metallurgy Sodium acetate Synthesis |
| Title | Synthesis of size-controllable Fe3O4 magnetic submicroparticles and its biocompatible evaluation in vitro |
| URI | https://link.springer.com/article/10.1007/s11771-016-3341-4 https://www.proquest.com/docview/1880823265 |
| Volume | 23 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Na9wwEBVtcmkPoZ9k082iQ08JAlmf1nEp2YaWtod2IT0ZyR4Fw8a7xE4g_fWVFHu9DWmhR2FJGOlZeuOZeYPQe1PlpVHeEE1VSYRTGbFCAPG6ChiqKqHT_44vX9X5Uny6kBd9Hnc7RLsPLsl0Uo_JbpnW0fRVhIejl4inaF9G0z2AeMnmWxCZWD53tCEyFUWSRtddaBuejW0mJN11hQWCkLFstEl4xtS25l1oy6Rx1mvspR85UVEspWWzQFdINGAG7-ljb_3n_TeS2gd-2HS9LV6gg56X4vk9kF6iJ9C8Qs931Apfo_r7XRPoYlu3eO1xW_8C0ge6r2L-FV4A_ybwlb1sYmIkbsNNG6P9NkPsHbZNheuuxa5ep9D3ro7DRr1xXDf4tg4TvkHLxdmPD-ekr9RASi54R6zOfbBLvIBgcCiglbQ-8ACa29waUN7lVIEQpWdUey-dt547LZWXJS09WP4W7TXrBg4R5tZYVymrQIMwjLrMAJQOtJCgFNgJosP6FWUvYx6raayKUYA5LnkRQ9fikhdigk62Qzb3Gh7_6jwdNqXoP-e2iKJ1ASRMyQk6HTZq5_HfJjv6r97v0DMWgZIyHador7u-geNAeTo3Q_vzjz8_n80S1H8DP4TuzQ |
| linkProvider | Springer Nature |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Nb9QwELVoOQAHBIWKhQI-9ASy5PgzPlaI1QLdcqAr9RbZybiKtM2uSKhUfj22N9ksqEXq0YptRfbEfpN58wahY1PlpVHeEE1VSYRTGbFCAPG6CjZUVUKn_x3zMzVbiK8X8qLP424HtvsQkkwn9ZjslmkdXV9FeDh6idhDDwMWyCOPa8FOtkZkYvnc0YfIVBRJGkN3oW14NraZkHQ3FBYAQsay0SfhGVPbmnehLZPGWa-xl37kREWxlJbNAlwh0YEZoqe3vfXf998Iav-Jw6brbfoMPe1xKT7ZGNJz9ACaA_RkR63wBap_3DQBLrZ1i1cet_VvID3RfRnzr_AU-HeBr-xlExMjcRtu2sj2Ww_cO2ybCtddi129StT3ro7DRr1xXDf4ug4TvkSL6efzTzPSV2ogJRe8I1bnPvglXkBwOBTQSlofcADNbW4NKO9yqkCI0jOqvZfOW8-dlsrLkpYeLD9E-82qgVcIc2usq5RVoEEYRl1mAEoHWkhQCuwE0WH9irKXMY_VNJbFKMAcl7yI1LW45IWYoA_bIeuNhsf_Oh8Nm1L0n3NbRNG6YCRMyQn6OGzUzuO7Jnt9r97v0aPZ-fy0OP1y9u0Nesyi0aSsxyO03_38BW8D_Oncu2TufwApv_As |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bi9QwFA66guiDeMXRVfPgkxI29zSPizqst1XQgX0rSXsihbUz2Crorzen005HUcHH0CSU5GvynZ5zvkPIY18XlbfJM8dtxXS0ggWtgSVXZwzVtXbD_463p_ZkpV-dmbOxzmk3RbtPLsltTgOqNLX90aZOR3Pim3AOzWDLVD6Gmb5ILuXTWCCsV_J4ByiPpXRne0JYFEya3Xi57ZWY21Ibvu8Wy2RBSDHbJ0pIu6t_l9tm0Dsb9faGnzqoLjakaMtMXRgaM5Mn9U9v_etdOBPc33yyw1W3vE6ujRyVHm9BdYNcgPYmubqnXHiLNB--t5k6dk1H14l2zQ9gY9D7OeZi0SWod5p-Dp9aTJKkXb51MfJvM8Xh0dDWtOk7Gpv1EAbfNzhs1h6nTUu_NXnC22S1fPHx2QkbqzawSmnVs-CKlG2UpCEbHxZ4bULKnIAXoQgebIoFt6B1lSR3KZmYQlLRGZtMxasEQd0hB-26hbuEquBDrG2w4EB7yaPwAFUEpw1YC2FB-LR-ZTVKmmNljfNyFmPGJS8xjA2XvNQL8mQ3ZLPV8_hX58NpU8rx0-5KFLDLIJHWLMjTaaP2Hv9tsnv_1fsRufz--bJ88_L09X1yRSJmhgTIQ3LQf_kKDzIT6uPDAe0_AYn59Gg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Synthesis+of+size-controllable+Fe3O4+magnetic+submicroparticles+and+its+biocompatible+evaluation+in+vitro&rft.jtitle=Journal+of+Central+South+University&rft.au=Tian%2C+Qing-hua&rft.au=Ning%2C+Wen-bo&rft.au=Wang%2C+Wei-jia&rft.au=Yuan%2C+Xiu-hong&rft.date=2016-11-01&rft.issn=2095-2899&rft.eissn=2227-5223&rft.volume=23&rft.issue=11&rft.spage=2784&rft.epage=2791&rft_id=info:doi/10.1007%2Fs11771-016-3341-4&rft.externalDBID=n%2Fa&rft.externalDocID=10_1007_s11771_016_3341_4 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2095-2899&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2095-2899&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2095-2899&client=summon |