Determination of naloxegol in human biological matrices

• Published in: Bioanalysis Vol. 9; no. 8; pp. 609 - 619
• Main Authors: Li, Yan, Hoffmann, Mark, Severin, Paul
• Format: Journal Article
• Language: English
• Published: England Future Science Ltd 01.04.2017
• Subjects: Analgesics, Opioid - adverse effects; Chromatography, Liquid - methods; clinical; Constipation - chemically induced; Constipation - drug therapy; Humans; LC-MS; Limit of Detection; Morphinans - blood; Morphinans - urine; naloxegol; Narcotic Antagonists - blood; Narcotic Antagonists - urine; Polyethylene Glycols; Receptors, Opioid, mu - antagonists & inhibitors; Solid Phase Extraction - methods; Tandem Mass Spectrometry - methods; clinical; naloxegol; LC–MS

Naloxegol is an oral peripherally acting μ-opioid receptor antagonist approved for the treatment of opioid-induced constipation. Sensitive, robust, bioanalytical methods were required to quantitate naloxegol in human biological matrices as part of the clinical development program. Analytical plasma...