Designer adjuvants for enhancing the efficacy of infectious disease and cancer vaccines based on suppression of regulatory T cell induction

• Published in: Immunology letters Vol. 122; no. 2; pp. 108 - 111
• Main Author: Mills, Kingston H.G
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 21.02.2009
• Subjects: Adjuvant; Adjuvants, Immunologic; Allergy and Immunology; Animals; Cancer Vaccines; Communicable Disease Control; Communicable Diseases - immunology; Delivery system; Humans; Immune Tolerance; Immunity, Innate; Immunosuppression; Infection; Neoplasms - immunology; Neoplasms - prevention & control; Regulatory T cell; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; T-Lymphocytes, Regulatory - pathology; Vaccination - methods; Vaccine; Vaccines - administration & dosage; Vaccines - adverse effects; Vaccines - immunology; Delivery system; Infection; Vaccine; Adjuvant; Regulatory T cell

Abstract Live attenuated or inactivated bacteria and viruses have formed the basis of many successful vaccines, including those that have eliminated smallpox and have almost eliminated poliovirus. The whole virus or bacteria approach remains the most effective means of generating protective immunity...