Effect of Trastuzumab on the Micellization Properties, Endocytic Pathways and Antitumor Activities of Polyurethane-based Drug Delivery System

Polyurethane micelles（PM）-based nanovehicles have shown great potential in targeted delivery of therapeutics and diagnostics into tumors.However,the pathways of PMs entering cancer cells and the action mechanism of targeting ligands have yet to be understood.In this contribution,the actively-targete...

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Published inChinese journal of polymer science Vol. 35; no. 8; p. 909
Main Authors Song, Ni-jia, Zhou, Li-juan, Liu, Wen-kai, He, Xue-ling, Pan, Zhi-cheng, Ding, Ming-ming, Wan, Xin-yuan, Li, Jie-hua, Tan, Hong, Luo, Feng, Fu, Qiang
Format Journal Article
LanguageEnglish
Published Beijing Chinese Chemical Society and Institute of Chemistry, CAS 01.08.2017
Springer Nature B.V
Subjects
Anticancer properties
Cancer
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Condensed Matter Physics
Drug delivery systems
Effectiveness
Formulations
Group dynamics
Immunotherapy
In vitro methods and tests
In vivo methods and tests
Industrial Chemistry/Chemical Engineering
Ligands
Micelles
Monoclonal antibodies
Polymer Sciences
Polyurethane resins
Targeted cancer therapy
Therapy
Tumors
内吞作用
化疗药物
单抗
基础
抗肿瘤活性
聚氨酯
胶束化
输送系统
Micelle
Polyurethane
Trastuzumab
Endocytic pathway
Antitumor
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Abstract Polyurethane micelles（PM）-based nanovehicles have shown great potential in targeted delivery of therapeutics and diagnostics into tumors.However,the pathways of PMs entering cancer cells and the action mechanism of targeting ligands have yet to be understood.In this contribution,the actively-targeted PM were developed using trastuzumab as a model targeting group.It was found that PM were mainly taken up by SKOV-3 tumor cells via a micropinocytosis process,while the incorporation of trastuzumab to PM enabled a receptor-mediated endocytosis of nanocarriers in cancer cells,leading to more efficient cell entry and enhanced anticancer efficacy of chemotherapeutic drugs both in vitro and in vivo.This study is advantageous to the understanding of the action mechanism of trastuzumab,and significant for the construction of improved formulations for targeted delivery and precise therapy.
AbstractList Polyurethane micelles（PM）-based nanovehicles have shown great potential in targeted delivery of therapeutics and diagnostics into tumors.However,the pathways of PMs entering cancer cells and the action mechanism of targeting ligands have yet to be understood.In this contribution,the actively-targeted PM were developed using trastuzumab as a model targeting group.It was found that PM were mainly taken up by SKOV-3 tumor cells via a micropinocytosis process,while the incorporation of trastuzumab to PM enabled a receptor-mediated endocytosis of nanocarriers in cancer cells,leading to more efficient cell entry and enhanced anticancer efficacy of chemotherapeutic drugs both in vitro and in vivo.This study is advantageous to the understanding of the action mechanism of trastuzumab,and significant for the construction of improved formulations for targeted delivery and precise therapy.
Polyurethane micelles (PM)-based nanovehicles have shown great potential in targeted delivery of therapeutics and diagnostics into tumors. However, the pathways of PMs entering cancer cells and the action mechanism of targeting ligands have yet to be understood. In this contribution, the actively-targeted PM were developed using trastuzumab as a model targeting group. It was found that PM were mainly taken up by SKOV-3 tumor cells via a micropinocytosis process, while the incorporation of trastuzumab to PM enabled a receptor-mediated endocytosis of nanocarriers in cancer cells, leading to more efficient cell entry and enhanced anticancer efficacy of chemotherapeutic drugs both in vitro and in vivo . This study is advantageous to the understanding of the action mechanism of trastuzumab, and significant for the construction of improved formulations for targeted delivery and precise therapy.
Polyurethane micelles (PM)-based nanovehicles have shown great potential in targeted delivery of therapeutics and diagnostics into tumors. However, the pathways of PMs entering cancer cells and the action mechanism of targeting ligands have yet to be understood. In this contribution, the actively-targeted PM were developed using trastuzumab as a model targeting group. It was found that PM were mainly taken up by SKOV-3 tumor cells via a micropinocytosis process, while the incorporation of trastuzumab to PM enabled a receptor-mediated endocytosis of nanocarriers in cancer cells, leading to more efficient cell entry and enhanced anticancer efficacy of chemotherapeutic drugs both in vitro and in vivo. This study is advantageous to the understanding of the action mechanism of trastuzumab, and significant for the construction of improved formulations for targeted delivery and precise therapy.
Author Ni-jia Song Li-juan Zhou Wen-kai Liu Xue-ling He Zhi-cheng Pan Ming-ming Ding Xin-yuan Wan Jie-hua Li Hong Tan Feng Luo Qiang Fu
AuthorAffiliation College of Polymer Science andEngineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China Key Laboratory of Rubber-Plastics, Ministry of Education/Shandong Provincial Key Laboratory of Rubber-Plastics, Qingdao University of Science ＆ Technology, Qingdao 266042, China Laboratory Animal Center of Sichuan University, Huaxi Clinical College, Sichuan University, Chengdu 610040, China
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Keywords Micelle
Polyurethane
Trastuzumab
Endocytic pathway
Antitumor
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Notes targeting targeted micelle understood diagnostics advantageous loaded anticancer conjugated incorporation
Polyurethane micelles（PM）-based nanovehicles have shown great potential in targeted delivery of therapeutics and diagnostics into tumors.However,the pathways of PMs entering cancer cells and the action mechanism of targeting ligands have yet to be understood.In this contribution,the actively-targeted PM were developed using trastuzumab as a model targeting group.It was found that PM were mainly taken up by SKOV-3 tumor cells via a micropinocytosis process,while the incorporation of trastuzumab to PM enabled a receptor-mediated endocytosis of nanocarriers in cancer cells,leading to more efficient cell entry and enhanced anticancer efficacy of chemotherapeutic drugs both in vitro and in vivo.This study is advantageous to the understanding of the action mechanism of trastuzumab,and significant for the construction of improved formulations for targeted delivery and precise therapy.
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Snippet Polyurethane micelles（PM）-based nanovehicles have shown great potential in targeted delivery of therapeutics and diagnostics into tumors.However,the pathways...
Polyurethane micelles (PM)-based nanovehicles have shown great potential in targeted delivery of therapeutics and diagnostics into tumors. However, the...
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SubjectTerms Anticancer properties
Cancer
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Condensed Matter Physics
Drug delivery systems
Effectiveness
Formulations
Group dynamics
Immunotherapy
In vitro methods and tests
In vivo methods and tests
Industrial Chemistry/Chemical Engineering
Ligands
Micelles
Monoclonal antibodies
Polymer Sciences
Polyurethane resins
Targeted cancer therapy
Therapy
Tumors
内吞作用
化疗药物
单抗
基础
抗肿瘤活性
聚氨酯
胶束化
输送系统
Title Effect of Trastuzumab on the Micellization Properties, Endocytic Pathways and Antitumor Activities of Polyurethane-based Drug Delivery System
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Volume 35
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