Intercellular adhesion molecule-1 is a surrogate biomarker for subclinical atherosclerosis in Type 2 diabetes mellitus

• Published in: Biomarkers in medicine Vol. 15; no. 2; pp. 121 - 132
• Main Authors: Sasikala, Thallapaneni, M Manohar, Suchitra, RR Bitla, Aparna, Sarala, S, Vaikkakara, Suresh
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.02.2021
• Subjects: Adult; Atherosclerosis - blood; Atherosclerosis - complications; Atherosclerosis - diagnosis; Biomarkers - blood; C-Reactive Protein - analysis; C-Reactive Protein - metabolism; Carotid Intima-Media Thickness; Case-Control Studies; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnosis; Female; Humans; inflammation; intercellular adhesion molecule-1; Intercellular Adhesion Molecule-1 - blood; Interleukin-10 - blood; Interleukin-6 - blood; Lipoproteins, LDL - blood; Male; Malondialdehyde - blood; Middle Aged; Oxidative Stress; ROC Curve; Serum Amyloid P-Component - analysis; Serum Amyloid P-Component - metabolism; subclinical atherosclerosis; surrogate biomarker; Type 2 diabetes mellitus; surrogate biomarker; carotid intima media thickness; inflammation; Type 2 diabetes mellitus; subclinical atherosclerosis; oxidative stress; intercellular adhesion molecule-1
• ISSN: 1752-0363; 1752-0371; 1752-0371
• DOI: 10.2217/bmm-2020-0428

We aimed to investigate biomarkers of inflammation, oxidative stress as surrogate markers of subclinical atherosclerosis in patients with Type 2 diabetes mellitus (T2DM). Subjects were grouped based on carotid intima media thickness (CIMT). Group 1: healthy controls (CIMT <0.57 mm); Group 2: T2DM without subclinical atherosclerosis (CIMT <0.57 mm); Group 3: T2DM with subclinical atherosclerosis (CIMT ≥0.57 mm). Significantly higher MDA, Hs-CRP, Ox-LDL, PTX-3, IL-6, ICAM-1 and lower FRAP, IL-10 levels in T2DM groups compared with controls (p = 0.001). Changes were more significant in Group 3 compared with Group 2. ICAM-1 had the highest sensitivity and specificity at a cut-off value of >40.34 ng/ml compared with Ox-LDL and PTX-3 (p < 0.001). ICAM can be considered as an alternate surrogate biomarker of CIMT.