Indole methylation protects diketopiperazine configuration in the maremycin biosynthetic pathway

• Published in: Science China. Chemistry Vol. 59; no. 9; pp. 1224 - 1228
• Main Authors: Lan, Yingxia, Zou, Yi, Huang, Tingting, Wang, Xiaozheng, Brock, Nelson L., Deng, Zixin, Lin, Shuangjun
• Format: Journal Article
• Language: English
• Published: Beijing Science China Press 01.09.2016; Springer Nature B.V
• Subjects: Biosynthesis; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Communications; D-色氨酸; Tryptophan; 保护; 吲哚; 哌嗪; 生物合成基因簇; 生物合成途径; 甲基化; 配置; maremycin; methyltransferase; epimerization; methylation; biosynthesis

The maremycin biosynthetic gene cluster has been identified in Streptomyces sp. B9173. Comparative metabolic profiling with knockout mutant strains led to the identification of new products correlated to the maremycin biosynthesis, in particular the ＂demethyl＂-maremycins with an unexpected D-tryptop...