Chromosome abnormalities in early pregnancy analyzed by direct chromosome preparation of chorionic villi

Chorionic villi chromosome analysis was performed on 1,186 cases of induced abortion between the 5th and 11th week of gestation. The total incidence of major chromosome abnormalities, including numerical and structural chromosomal changes as well as mosaics and polyploids, was 4.5% (53 cases). The m...

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Bibliographic Details
Published inHuman genetics Vol. 83; no. 3; p. 277
Main Authors Zhou, X T, Tong, H S, Wong, S G, Shen, Q E, Fu, X W, Cui, Y Q
Format Journal Article
LanguageEnglish
Published Germany 01.10.1989
Subjects
Abortion, Induced
Adolescent
Adult
Chorionic Villi - ultrastructure
Chromosome Aberrations
Female
Humans
Maternal Age
Middle Aged
Pregnancy
Pregnancy Trimester, First
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Summary:Chorionic villi chromosome analysis was performed on 1,186 cases of induced abortion between the 5th and 11th week of gestation. The total incidence of major chromosome abnormalities, including numerical and structural chromosomal changes as well as mosaics and polyploids, was 4.5% (53 cases). The most common abnormalities were trisomy 21 (5 cases), trisomy 16 (4 cases), and monosomy X (4 cases). The incidence of chromosome abnormalities increased with the advancing age of the mother.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00285172