Protective effects of 3,4-seco-lupane type triterpenes from Acanthopanax senticosus against advanced glycation endproducts
Advanced glycation end products (AGEs) are thought to be directly involved in diabetes mellitus and aging. In this study, the protective activities of 3,4-seco-lupane type triterpenes (chiisanogenin and chiisanoside) from Acanthopanax senticosus against the formation of AGEs were examined using in v...
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Published in | Horticulture, environment and biotechnology Vol. 53; no. 3; pp. 242 - 246 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Korea
Korean Society for Horticulture and Science
01.06.2012
한국원예학회 |
Subjects | |
Online Access | Get full text |
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Summary: | Advanced glycation end products (AGEs) are thought to be directly involved in diabetes mellitus and aging. In this study, the protective activities of 3,4-seco-lupane type triterpenes (chiisanogenin and chiisanoside) from Acanthopanax senticosus against the formation of AGEs were examined using in vitro glycation reactions. Of the two isolated compounds, chiisanogenin exhibited strong inhibitory activity against the formation of AGEs. The inhibitory activity of chiisanogenin was similar level in 50 μM treatment with the AGE inhibitor aminoguanidine, which was used as a positive control. These results suggest that chiisanogenin from A. senticosus is a bioactive component that contributes to glycation-associated diseases. |
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Bibliography: | F01 G704-000103.2012.53.3.008 |
ISSN: | 2211-3452 2211-3460 |
DOI: | 10.1007/s13580-012-0030-6 |