ALKBH5-mediated m6A mRNA methylation governs human embryonic stem cell cardiac commitment

• Published in: Molecular therapy. Nucleic acids Vol. 26; pp. 22 - 33
• Main Authors: Han, Zhenbo, Xu, Zihang, Yu, Ying, Cao, Yang, Bao, Zhengyi, Gao, Xinlu, Ye, Danyu, Yan, Gege, Gong, Rui, Xu, Juan, Zhang, Lai, Ma, Wenya, Wang, Xiuxiu, Yang, Fan, Lei, Hong, Tian, Ye, Hu, Shijun, Bamba, Djibril, Li, Ying, Li, Desheng, Li, Changzhu, Wang, Ning, Zhang, Ying, Pan, Zhenwei, Yang, Baofeng, Cai, Benzhi
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 03.12.2021; American Society of Gene & Cell Therapy; Elsevier
• Subjects: Original

N6-methyladenosine (m6A), as the most abundant modification of mammalian messenger RNAs, is essential for tissue development and pathogenesis. However, the biological significance of m6A methylation in cardiac differentiation and development remains largely unknown. Here, we identify that the downre...