Effects of Ginseng Consumption on Cardiovascular Health Biomarkers in Adults: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

ABSTRACT Ginseng, with various pharmacological activities, has received increasing attention to improve cardiovascular health (CVH). Therefore, this meta‐analysis synthesized the effect of ginseng consumption on biomarkers of CVH in adults. A systematic search was performed in the databases of PubMe...

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Published inPhytotherapy research Vol. 38; no. 12; pp. 5873 - 5900
Main Authors Zhang, Xiao‐Feng, Min, Rui‐Xue, Wang, Zhen, Qi, Yue, Li, Ruo‐Nan, Fan, Jian‐Ming
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.12.2024
Wiley Subscription Services, Inc
Subjects
adipokines
Adult
Adults
Biomarkers
Biomarkers - blood
Blood pressure
Blood Pressure - drug effects
Body composition
C-reactive protein
C-Reactive Protein - analysis
cardiovascular diseases
Cardiovascular Diseases - prevention & control
cardiovascular health
Cholesterol
Clinical trials
Composition effects
confidence interval
Consumption
Effectiveness
Ginseng
ginseng consumption
glucose
Glucose metabolism
Heterogeneity
Humans
Insulin Resistance
Interleukin 6
Lipid metabolism
Lipids
Low density lipoprotein
low density lipoprotein cholesterol
Meta-analysis
Metabolism
Panax
Panax - chemistry
phytotherapy
Pressure effects
randomized controlled trials
Randomized Controlled Trials as Topic
Subgroups
systematic review
systolic blood pressure
Vascular Stiffness - drug effects
ginseng consumption
cardiovascular diseases
meta‐analysis
randomized controlled trials
cardiovascular health
Online AccessGet full text
ISSN0951-418X
1099-1573
1099-1573
DOI10.1002/ptr.8339

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Abstract ABSTRACT Ginseng, with various pharmacological activities, has received increasing attention to improve cardiovascular health (CVH). Therefore, this meta‐analysis synthesized the effect of ginseng consumption on biomarkers of CVH in adults. A systematic search was performed in the databases of PubMed, Scopus, Web of Science, Embase, and the Cochrane Library through July 24, 2023 to screen out English‐language randomized controlled trials (RCTs) evaluating the effects of ginseng consumption on body composition, blood pressure, vascular stiffness, lipid metabolism, glucose metabolism, insulin resistance, inflammatory cytokines, and adipocytokines in adults. The weighted mean difference (WMD) and 95% confidence interval (CI) were used to evaluate the overall effect size, and STATA 12.0 was used for comprehensive analysis. Forty‐five studies were included in the meta‐analysis. Ginseng consumption significantly reduced systolic blood pressure (SBP) (WMD = −2.57 mmHg, 95% CI = −4.99 to −0.14, p = 0.038), total cholesterol (TC) (WMD = −4.40 mg/dL, 95% CI = −8.67 to −0.132, p = 0.043), low density lipoprotein cholesterol (LDL‐C) (WMD = −2.81 mg/dL, 95% CI = −4.89 to −0.72, p = 0.008), C‐reactive protein (CRP) (WMD = −0.41 mg/L, 95% CI = −0.73 to −0.10, p = 0.010), and interleukin‐6 (IL‐6) (WMD = −2.82 pg./mL, 95% CI = −4.31 to −1.32, p < 0.001). Subgroup analyses suggested that supplementation with ginseng for less than 12 weeks significantly reduced SBP, but 12 weeks or more improved TC and CRP. Ginseng consumption on SBP, TC, and CRP seemed to be more effective on unhealthy participants. The meta‐analysis showed that ginseng consumption might have the potential to improve SBP, TC, LDL‐C, CRP, and IL‐6. These findings suggest that ginseng is a potential candidate for the maintenance of CVH. However, our results had high heterogeneity. Future high‐quality studies are needed to firmly establish the clinical efficacy of ginseng consumption.
AbstractList Ginseng, with various pharmacological activities, has received increasing attention to improve cardiovascular health (CVH). Therefore, this meta-analysis synthesized the effect of ginseng consumption on biomarkers of CVH in adults. A systematic search was performed in the databases of PubMed, Scopus, Web of Science, Embase, and the Cochrane Library through July 24, 2023 to screen out English-language randomized controlled trials (RCTs) evaluating the effects of ginseng consumption on body composition, blood pressure, vascular stiffness, lipid metabolism, glucose metabolism, insulin resistance, inflammatory cytokines, and adipocytokines in adults. The weighted mean difference (WMD) and 95% confidence interval (CI) were used to evaluate the overall effect size, and STATA 12.0 was used for comprehensive analysis. Forty-five studies were included in the meta-analysis. Ginseng consumption significantly reduced systolic blood pressure (SBP) (WMD = -2.57 mmHg, 95% CI = -4.99 to -0.14, p = 0.038), total cholesterol (TC) (WMD = -4.40 mg/dL, 95% CI = -8.67 to -0.132, p = 0.043), low density lipoprotein cholesterol (LDL-C) (WMD = -2.81 mg/dL, 95% CI = -4.89 to -0.72, p = 0.008), C-reactive protein (CRP) (WMD = -0.41 mg/L, 95% CI = -0.73 to -0.10, p = 0.010), and interleukin-6 (IL-6) (WMD = -2.82 pg./mL, 95% CI = -4.31 to -1.32, p < 0.001). Subgroup analyses suggested that supplementation with ginseng for less than 12 weeks significantly reduced SBP, but 12 weeks or more improved TC and CRP. Ginseng consumption on SBP, TC, and CRP seemed to be more effective on unhealthy participants. The meta-analysis showed that ginseng consumption might have the potential to improve SBP, TC, LDL-C, CRP, and IL-6. These findings suggest that ginseng is a potential candidate for the maintenance of CVH. However, our results had high heterogeneity. Future high-quality studies are needed to firmly establish the clinical efficacy of ginseng consumption.
ABSTRACT Ginseng, with various pharmacological activities, has received increasing attention to improve cardiovascular health (CVH). Therefore, this meta‐analysis synthesized the effect of ginseng consumption on biomarkers of CVH in adults. A systematic search was performed in the databases of PubMed, Scopus, Web of Science, Embase, and the Cochrane Library through July 24, 2023 to screen out English‐language randomized controlled trials (RCTs) evaluating the effects of ginseng consumption on body composition, blood pressure, vascular stiffness, lipid metabolism, glucose metabolism, insulin resistance, inflammatory cytokines, and adipocytokines in adults. The weighted mean difference (WMD) and 95% confidence interval (CI) were used to evaluate the overall effect size, and STATA 12.0 was used for comprehensive analysis. Forty‐five studies were included in the meta‐analysis. Ginseng consumption significantly reduced systolic blood pressure (SBP) (WMD = −2.57 mmHg, 95% CI = −4.99 to −0.14, p = 0.038), total cholesterol (TC) (WMD = −4.40 mg/dL, 95% CI = −8.67 to −0.132, p = 0.043), low density lipoprotein cholesterol (LDL‐C) (WMD = −2.81 mg/dL, 95% CI = −4.89 to −0.72, p = 0.008), C‐reactive protein (CRP) (WMD = −0.41 mg/L, 95% CI = −0.73 to −0.10, p = 0.010), and interleukin‐6 (IL‐6) (WMD = −2.82 pg./mL, 95% CI = −4.31 to −1.32, p < 0.001). Subgroup analyses suggested that supplementation with ginseng for less than 12 weeks significantly reduced SBP, but 12 weeks or more improved TC and CRP. Ginseng consumption on SBP, TC, and CRP seemed to be more effective on unhealthy participants. The meta‐analysis showed that ginseng consumption might have the potential to improve SBP, TC, LDL‐C, CRP, and IL‐6. These findings suggest that ginseng is a potential candidate for the maintenance of CVH. However, our results had high heterogeneity. Future high‐quality studies are needed to firmly establish the clinical efficacy of ginseng consumption.
Ginseng, with various pharmacological activities, has received increasing attention to improve cardiovascular health (CVH). Therefore, this meta‐analysis synthesized the effect of ginseng consumption on biomarkers of CVH in adults. A systematic search was performed in the databases of PubMed, Scopus, Web of Science, Embase, and the Cochrane Library through July 24, 2023 to screen out English‐language randomized controlled trials (RCTs) evaluating the effects of ginseng consumption on body composition, blood pressure, vascular stiffness, lipid metabolism, glucose metabolism, insulin resistance, inflammatory cytokines, and adipocytokines in adults. The weighted mean difference (WMD) and 95% confidence interval (CI) were used to evaluate the overall effect size, and STATA 12.0 was used for comprehensive analysis. Forty‐five studies were included in the meta‐analysis. Ginseng consumption significantly reduced systolic blood pressure (SBP) (WMD = −2.57 mmHg, 95% CI = −4.99 to −0.14, p = 0.038), total cholesterol (TC) (WMD = −4.40 mg/dL, 95% CI = −8.67 to −0.132, p = 0.043), low density lipoprotein cholesterol (LDL‐C) (WMD = −2.81 mg/dL, 95% CI = −4.89 to −0.72, p = 0.008), C‐reactive protein (CRP) (WMD = −0.41 mg/L, 95% CI = −0.73 to −0.10, p = 0.010), and interleukin‐6 (IL‐6) (WMD = −2.82 pg./mL, 95% CI = −4.31 to −1.32, p < 0.001). Subgroup analyses suggested that supplementation with ginseng for less than 12 weeks significantly reduced SBP, but 12 weeks or more improved TC and CRP. Ginseng consumption on SBP, TC, and CRP seemed to be more effective on unhealthy participants. The meta‐analysis showed that ginseng consumption might have the potential to improve SBP, TC, LDL‐C, CRP, and IL‐6. These findings suggest that ginseng is a potential candidate for the maintenance of CVH. However, our results had high heterogeneity. Future high‐quality studies are needed to firmly establish the clinical efficacy of ginseng consumption.
Ginseng, with various pharmacological activities, has received increasing attention to improve cardiovascular health (CVH). Therefore, this meta‐analysis synthesized the effect of ginseng consumption on biomarkers of CVH in adults. A systematic search was performed in the databases of PubMed, Scopus, Web of Science, Embase, and the Cochrane Library through July 24, 2023 to screen out English‐language randomized controlled trials (RCTs) evaluating the effects of ginseng consumption on body composition, blood pressure, vascular stiffness, lipid metabolism, glucose metabolism, insulin resistance, inflammatory cytokines, and adipocytokines in adults. The weighted mean difference (WMD) and 95% confidence interval (CI) were used to evaluate the overall effect size, and STATA 12.0 was used for comprehensive analysis. Forty‐five studies were included in the meta‐analysis. Ginseng consumption significantly reduced systolic blood pressure (SBP) (WMD = −2.57 mmHg, 95% CI = −4.99 to −0.14, p  = 0.038), total cholesterol (TC) (WMD = −4.40 mg/dL, 95% CI = −8.67 to −0.132, p  = 0.043), low density lipoprotein cholesterol (LDL‐C) (WMD = −2.81 mg/dL, 95% CI = −4.89 to −0.72, p  = 0.008), C‐reactive protein (CRP) (WMD = −0.41 mg/L, 95% CI = −0.73 to −0.10, p  = 0.010), and interleukin‐6 (IL‐6) (WMD = −2.82 pg./mL, 95% CI = −4.31 to −1.32, p  < 0.001). Subgroup analyses suggested that supplementation with ginseng for less than 12 weeks significantly reduced SBP, but 12 weeks or more improved TC and CRP. Ginseng consumption on SBP, TC, and CRP seemed to be more effective on unhealthy participants. The meta‐analysis showed that ginseng consumption might have the potential to improve SBP, TC, LDL‐C, CRP, and IL‐6. These findings suggest that ginseng is a potential candidate for the maintenance of CVH. However, our results had high heterogeneity. Future high‐quality studies are needed to firmly establish the clinical efficacy of ginseng consumption.
Ginseng, with various pharmacological activities, has received increasing attention to improve cardiovascular health (CVH). Therefore, this meta-analysis synthesized the effect of ginseng consumption on biomarkers of CVH in adults. A systematic search was performed in the databases of PubMed, Scopus, Web of Science, Embase, and the Cochrane Library through July 24, 2023 to screen out English-language randomized controlled trials (RCTs) evaluating the effects of ginseng consumption on body composition, blood pressure, vascular stiffness, lipid metabolism, glucose metabolism, insulin resistance, inflammatory cytokines, and adipocytokines in adults. The weighted mean difference (WMD) and 95% confidence interval (CI) were used to evaluate the overall effect size, and STATA 12.0 was used for comprehensive analysis. Forty-five studies were included in the meta-analysis. Ginseng consumption significantly reduced systolic blood pressure (SBP) (WMD = -2.57 mmHg, 95% CI = -4.99 to -0.14, p = 0.038), total cholesterol (TC) (WMD = -4.40 mg/dL, 95% CI = -8.67 to -0.132, p = 0.043), low density lipoprotein cholesterol (LDL-C) (WMD = -2.81 mg/dL, 95% CI = -4.89 to -0.72, p = 0.008), C-reactive protein (CRP) (WMD = -0.41 mg/L, 95% CI = -0.73 to -0.10, p = 0.010), and interleukin-6 (IL-6) (WMD = -2.82 pg./mL, 95% CI = -4.31 to -1.32, p < 0.001). Subgroup analyses suggested that supplementation with ginseng for less than 12 weeks significantly reduced SBP, but 12 weeks or more improved TC and CRP. Ginseng consumption on SBP, TC, and CRP seemed to be more effective on unhealthy participants. The meta-analysis showed that ginseng consumption might have the potential to improve SBP, TC, LDL-C, CRP, and IL-6. These findings suggest that ginseng is a potential candidate for the maintenance of CVH. However, our results had high heterogeneity. Future high-quality studies are needed to firmly establish the clinical efficacy of ginseng consumption.Ginseng, with various pharmacological activities, has received increasing attention to improve cardiovascular health (CVH). Therefore, this meta-analysis synthesized the effect of ginseng consumption on biomarkers of CVH in adults. A systematic search was performed in the databases of PubMed, Scopus, Web of Science, Embase, and the Cochrane Library through July 24, 2023 to screen out English-language randomized controlled trials (RCTs) evaluating the effects of ginseng consumption on body composition, blood pressure, vascular stiffness, lipid metabolism, glucose metabolism, insulin resistance, inflammatory cytokines, and adipocytokines in adults. The weighted mean difference (WMD) and 95% confidence interval (CI) were used to evaluate the overall effect size, and STATA 12.0 was used for comprehensive analysis. Forty-five studies were included in the meta-analysis. Ginseng consumption significantly reduced systolic blood pressure (SBP) (WMD = -2.57 mmHg, 95% CI = -4.99 to -0.14, p = 0.038), total cholesterol (TC) (WMD = -4.40 mg/dL, 95% CI = -8.67 to -0.132, p = 0.043), low density lipoprotein cholesterol (LDL-C) (WMD = -2.81 mg/dL, 95% CI = -4.89 to -0.72, p = 0.008), C-reactive protein (CRP) (WMD = -0.41 mg/L, 95% CI = -0.73 to -0.10, p = 0.010), and interleukin-6 (IL-6) (WMD = -2.82 pg./mL, 95% CI = -4.31 to -1.32, p < 0.001). Subgroup analyses suggested that supplementation with ginseng for less than 12 weeks significantly reduced SBP, but 12 weeks or more improved TC and CRP. Ginseng consumption on SBP, TC, and CRP seemed to be more effective on unhealthy participants. The meta-analysis showed that ginseng consumption might have the potential to improve SBP, TC, LDL-C, CRP, and IL-6. These findings suggest that ginseng is a potential candidate for the maintenance of CVH. However, our results had high heterogeneity. Future high-quality studies are needed to firmly establish the clinical efficacy of ginseng consumption.
Author Zhang, Xiao‐Feng
Qi, Yue
Li, Ruo‐Nan
Fan, Jian‐Ming
Min, Rui‐Xue
Wang, Zhen
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ISSN 0951-418X
1099-1573
IngestDate Fri Jul 11 07:36:31 EDT 2025
Fri Jul 11 02:09:28 EDT 2025
Fri Jul 25 12:15:52 EDT 2025
Fri Aug 01 03:41:36 EDT 2025
Tue Jul 01 02:13:31 EDT 2025
Sun Jul 06 04:45:00 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 12
Keywords ginseng consumption
cardiovascular diseases
meta‐analysis
randomized controlled trials
cardiovascular health
Language English
License 2024 John Wiley & Sons Ltd.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c3439-bf0fe28c479a349c9e46f65234f67ce925f244f90d669be3927cf562748731b03
Notes Funding
This work was supported by the National Natural Science Foundation of China (grant number: 31372453) and the Major Collaborative Innovation Project of Nanyang City, Henan Province, China (grant number: 21XTCX12005).
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Snippet ABSTRACT Ginseng, with various pharmacological activities, has received increasing attention to improve cardiovascular health (CVH). Therefore, this...
Ginseng, with various pharmacological activities, has received increasing attention to improve cardiovascular health (CVH). Therefore, this meta‐analysis...
Ginseng, with various pharmacological activities, has received increasing attention to improve cardiovascular health (CVH). Therefore, this meta-analysis...
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SubjectTerms adipokines
Adult
Adults
Biomarkers
Biomarkers - blood
Blood pressure
Blood Pressure - drug effects
Body composition
C-reactive protein
C-Reactive Protein - analysis
cardiovascular diseases
Cardiovascular Diseases - prevention & control
cardiovascular health
Cholesterol
Clinical trials
Composition effects
confidence interval
Consumption
Effectiveness
Ginseng
ginseng consumption
glucose
Glucose metabolism
Heterogeneity
Humans
Insulin Resistance
Interleukin 6
Lipid metabolism
Lipids
Low density lipoprotein
low density lipoprotein cholesterol
Meta-analysis
Metabolism
Panax
Panax - chemistry
phytotherapy
Pressure effects
randomized controlled trials
Randomized Controlled Trials as Topic
Subgroups
systematic review
systolic blood pressure
Vascular Stiffness - drug effects
Title Effects of Ginseng Consumption on Cardiovascular Health Biomarkers in Adults: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fptr.8339
https://www.ncbi.nlm.nih.gov/pubmed/39387709
https://www.proquest.com/docview/3143046337
https://www.proquest.com/docview/3116333199
https://www.proquest.com/docview/3154244865
Volume 38
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